@inproceedings{6eae08043ccd4171af6f44dc3705aa9b,
title = "Neutrophils migrate longer distances in moving microfluidic concentration gradients compared to static ones",
abstract = "We present the use of our recently developed microfluidic quadrupole (MQ) to generate controllable microfluidic floating concentration gradients of 25 ng·ml-1 Interleukin 8 (IL-8), and challenge neutrophils cultured in petri-dishes with stationary and moving gradients. The dynamic responses of individual neutrophils were analyzed and we found that the migration length of neutrophils is correlated to their initial position within the stationary gradient. However, for moving gradients this correlation vanishes, while at the same time neutrophils migrate over longer distances. Our results and demonstrated experimentation lay the foundation for future novel chemotaxis assays under moving gradients of different shapes and speeds.",
keywords = "Chemotaxis, Floating gradients, Microfluidic probe, Microfluidic quadrupole, Neutrophils",
author = "Qasaimeh, {Mohammad A.} and M{\'e}lina Astolfi and Michal Pyzik and Silvia Vidal and David Juncker",
year = "2013",
language = "English (US)",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
publisher = "Chemical and Biological Microsystems Society",
pages = "2007--2009",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",
}