TY - JOUR
T1 - New insights into co-transcriptional sorting of mRNA for cytoplasmic transport during development
AU - Percipalle, Piergiorgio
N1 - Funding Information:
I thank Nanaho Fukuda and Aishe Sarshad for helpful insights into the manuscript. Our work is supported by grants from the Swedish Research Council (Vetenskapsrådet) and Cancerfonden (The Swedish Cancer Society).
PY - 2014/8
Y1 - 2014/8
N2 - During mRNA biogenesis regulation of mRNA transport and localization is an essential step. It guarantees asymmetric protein distribution across the cell necessary for specialized cellular functions, and it is a driving force for cellular differentiation and development. mRNA transport and localization depends on the interactions between cis-acting elements located across the transcript with cellular transacting factors, and emerging data supports also the involvement of structural proteins such as actin. These synergies are believed to occur co-transcriptionally when the nascent transcript is packaged into ribonucleoprotein complexes, and to determine a translationally repressed form of the mRNA only compatible with transport. The aim of this review is to highlight part of the molecular circuitry behind the decisions that control assembly of translationally repressed and de-repressed ribonucleoprotein complexes, compatible with mRNA transport or localization. I will specifically place the impact of these mechanisms in the context of spermatogenesis.
AB - During mRNA biogenesis regulation of mRNA transport and localization is an essential step. It guarantees asymmetric protein distribution across the cell necessary for specialized cellular functions, and it is a driving force for cellular differentiation and development. mRNA transport and localization depends on the interactions between cis-acting elements located across the transcript with cellular transacting factors, and emerging data supports also the involvement of structural proteins such as actin. These synergies are believed to occur co-transcriptionally when the nascent transcript is packaged into ribonucleoprotein complexes, and to determine a translationally repressed form of the mRNA only compatible with transport. The aim of this review is to highlight part of the molecular circuitry behind the decisions that control assembly of translationally repressed and de-repressed ribonucleoprotein complexes, compatible with mRNA transport or localization. I will specifically place the impact of these mechanisms in the context of spermatogenesis.
KW - Actin
KW - Cellular development
KW - Germ cells
KW - HnRNP proteins
KW - Localized translation
KW - MRNA transport and localization
KW - RNPs
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U2 - 10.1016/j.semcdb.2014.03.009
DO - 10.1016/j.semcdb.2014.03.009
M3 - Review article
C2 - 24657194
AN - SCOPUS:84904459382
SN - 1084-9521
VL - 32
SP - 55
EP - 62
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -