New insights into the classification and nomenclature of cortical GABAergic interneurons

Javier Defelipe, Pedro L. López-Cruz, Ruth Benavides-Piccione, Concha Bielza, Pedro Larrañaga, Stewart Anderson, Andreas Burkhalter, Bruno Cauli, Alfonso Fairén, Dirk Feldmeyer, Gord Fishell, David Fitzpatrick, Tamás F. Freund, Guillermo González-Burgos, Shaul Hestrin, Sean Hill, Patrick R. Hof, Josh Huang, Edward G. Jones, Yasuo KawaguchiZoltán Kisvárday, Yoshiyuki Kubota, David A. Lewis, Oscar Marín, Henry Markram, Chris J. McBain, Hanno S. Meyer, Hannah Monyer, Sacha B. Nelson, Kathleen Rockland, Jean Rossier, John L.R. Rubenstein, Bernardo Rudy, Massimo Scanziani, Gordon M. Shepherd, Chet C. Sherwood, Jochen F. Staiger, Gábor Tamás, Alex Thomson, Yun Weng, Rafael Yuste, Giorgio A. Ascoli

Research output: Contribution to journalArticle

Abstract

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.

Original languageEnglish (US)
Pages (from-to)202-216
Number of pages15
JournalNature Reviews Neuroscience
Volume14
Issue number3
DOIs
StatePublished - Mar 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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    Defelipe, J., López-Cruz, P. L., Benavides-Piccione, R., Bielza, C., Larrañaga, P., Anderson, S., Burkhalter, A., Cauli, B., Fairén, A., Feldmeyer, D., Fishell, G., Fitzpatrick, D., Freund, T. F., González-Burgos, G., Hestrin, S., Hill, S., Hof, P. R., Huang, J., Jones, E. G., ... Ascoli, G. A. (2013). New insights into the classification and nomenclature of cortical GABAergic interneurons. Nature Reviews Neuroscience, 14(3), 202-216. https://doi.org/10.1038/nrn3444