New method to diagnose joints affected by systemic lupus erythematosus based on frequency-domain optical transmission

A. Marone, Y. Kim, G. Danias, K. E. Neville, A. T. Frantz, T. Kapoor, L. Geraldino-Pardilla, A. D. Askanase, A. H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution


It is estimated that in the USA 1.5 million people suffer from systemic lupus erythematosus (SLE). This autoimmune disease often involves joints, and more than 90% of those affected will experience joint pain, stiffness and swelling at some time during the course of their illness. It is currently difficult to both diagnose and estimate the severity of lupus, because signs and symptoms vary considerably from person to person and there is no single diagnostic test for it. We explored the clinical utility of frequency-domain optical tomography (FDOT) to distinguish finger joints affected by SLE from healthy ones of volunteers. The proximal interphalangeal joints (PIP) of the 2nd to the 5th digit from both hands of 10 SLE patients and 4 healthy volunteers were examined. This resulted in a total of 80 joints affected by SLE and 32 healthy joints. The FDOT system was operated at a frequency of 600MHz. The laser diode employed produced a 1-mm beam at 670nm light, which was guided to 11 positions on the top of the PIP joints. At every location, using an exposure time of 80 ms for 16 phase steps, transmission images were acquired using an ICCD camera. First results of the analysis of the amplitude and phase shift of the images acquired show a sensitivity of 100% and a specificity of 80% to distinguish between joints of healthy volunteers and SLE patients.

Original languageEnglish (US)
Title of host publicationOptical Tomography and Spectroscopy of Tissue XIII
EditorsPaola Taroni, Sergio Fantini
ISBN (Electronic)9781510623903
StatePublished - 2019
EventOptical Tomography and Spectroscopy of Tissue XIII 2019 - San Francisco, United States
Duration: Feb 4 2019Feb 6 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Tomography and Spectroscopy of Tissue XIII 2019
Country/TerritoryUnited States
CitySan Francisco


  • Finger joints
  • Frequency-domain optical tomography
  • SLE
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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