TY - JOUR
T1 - New players in phototherapy
T2 - photopharmacology and bio-integrated optoelectronics
AU - Morstein, Johannes
AU - Trauner, Dirk
N1 - Publisher Copyright:
© 2019
PY - 2019/6
Y1 - 2019/6
N2 - Photodynamic therapy and phototherapy are used in the clinic to treat dermatological conditions, cancer, macular degeneration, and a variety of other diseases. Despite their long history and widespread application, the scope of these therapeutic approaches has been limited by a lack of specificity and challenges with light delivery. In recent years, much progress has been made in these regards. Photopharmacology has provided drug-like molecules that change their efficacy upon irradiation and allow for the optical control of a wide range of defined biological targets. Many photopharmaceuticals are now used in vivo and some show promising results in preclinical development. At the same time, new bioelectronics for subdermal light delivery have been engineered that could enable phototherapy deep in tissue, for example within the human brain. These developments could increase the impact of photodynamic therapy in human precision medicine.
AB - Photodynamic therapy and phototherapy are used in the clinic to treat dermatological conditions, cancer, macular degeneration, and a variety of other diseases. Despite their long history and widespread application, the scope of these therapeutic approaches has been limited by a lack of specificity and challenges with light delivery. In recent years, much progress has been made in these regards. Photopharmacology has provided drug-like molecules that change their efficacy upon irradiation and allow for the optical control of a wide range of defined biological targets. Many photopharmaceuticals are now used in vivo and some show promising results in preclinical development. At the same time, new bioelectronics for subdermal light delivery have been engineered that could enable phototherapy deep in tissue, for example within the human brain. These developments could increase the impact of photodynamic therapy in human precision medicine.
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U2 - 10.1016/j.cbpa.2019.03.013
DO - 10.1016/j.cbpa.2019.03.013
M3 - Review article
C2 - 31108317
AN - SCOPUS:85065724947
SN - 1367-5931
VL - 50
SP - 145
EP - 151
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
ER -