New Views of Old Proteins: Clarifying the Enigmatic Proteome

Kristin E. Burnum-Johnson; Thomas P. Conrads; Richard R. Drake; Amy E. Herr; Ravi Iyengar; Ryan T. Kelly; Emma Lundberg; Michael J. MacCoss; Alexandra Naba; Garry P. Nolan; Pavel A. Pevzner; Karin D. Rodland; Salvatore Sechi; Nikolai Slavov; Jeffrey M. Spraggins; Jennifer E. Van Eyk; Marc Vidal; Christine Vogel; David R. Walt; Neil L. Kelleher

doi:10.1016/j.mcpro.2022.100254

New Views of Old Proteins: Clarifying the Enigmatic Proteome

Kristin E. Burnum-Johnson, Thomas P. Conrads, Richard R. Drake, Amy E. Herr, Ravi Iyengar, Ryan T. Kelly, Emma Lundberg, Michael J. MacCoss, Alexandra Naba, Garry P. Nolan, Pavel A. Pevzner, Karin D. Rodland, Salvatore Sechi, Nikolai Slavov, Jeffrey M. Spraggins, Jennifer E. Van Eyk, Marc Vidal, Christine Vogel, David R. Walt, Neil L. Kelleher

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.

Original language	English (US)
Article number	100254
Journal	Molecular and Cellular Proteomics
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.mcpro.2022.100254
State	Published - Jul 2022

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Molecular Biology

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Burnum-Johnson, K. E., Conrads, T. P., Drake, R. R., Herr, A. E., Iyengar, R., Kelly, R. T., Lundberg, E., MacCoss, M. J., Naba, A., Nolan, G. P., Pevzner, P. A., Rodland, K. D., Sechi, S., Slavov, N., Spraggins, J. M., Van Eyk, J. E., Vidal, M., Vogel, C., Walt, D. R., & Kelleher, N. L. (2022). New Views of Old Proteins: Clarifying the Enigmatic Proteome. Molecular and Cellular Proteomics, 21(7), Article 100254. https://doi.org/10.1016/j.mcpro.2022.100254

Burnum-Johnson, KE, Conrads, TP, Drake, RR, Herr, AE, Iyengar, R, Kelly, RT, Lundberg, E, MacCoss, MJ, Naba, A, Nolan, GP, Pevzner, PA, Rodland, KD, Sechi, S, Slavov, N, Spraggins, JM, Van Eyk, JE, Vidal, M, Vogel, C, Walt, DR & Kelleher, NL 2022, 'New Views of Old Proteins: Clarifying the Enigmatic Proteome', Molecular and Cellular Proteomics, vol. 21, no. 7, 100254. https://doi.org/10.1016/j.mcpro.2022.100254

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abstract = "All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.",

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AU - Lundberg, Emma

AU - MacCoss, Michael J.

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New Views of Old Proteins: Clarifying the Enigmatic Proteome

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