@article{1d65d1085ecd491aa58d808adf0f6bd2,
title = "Newly synthesized class II MHC chains are required for VSV G presentation to CTL clones",
abstract = "Mechanisms of antigen processing and presentation to thymus-derived lymphocytes have been under intense study for several years, focusing on both Class I-restricted antigen presentation and Class II-MHC restricted responses. The studies described here examine the processing and presentation of exogenously provided soluble glycoprotein of the vesicular stomatitis virus and as well as newly synthesized viral glycoprotein. Evidence is provided that newly synthesized Class II MHC chains are required for cell surface expression of processed glycoprotein determinants irrespective of the origin of the viral antigen. Inhibitors of distinct cellular processes, including ammonium chloride, emetine, and Brefeldin A, have been used to dissect the pathways utilized.",
author = "Reiss, {Carol S.} and Gapud, {Carolina P.} and Walter Keil",
note = "Funding Information: This work was supported by grants from the National Institutes of Health ROl AI18083 to C.S.R. and R37 AI20896 to Alice Huang (supporting W.K.), and a grant from the Elsa U. Pardee Foundation to C.S.R. The authors gratefully acknowledge Dr. Jack Rose, Yale University, and Dr. Bernard Moss, NIH, for gift of plasmids, vaccinia virus recombinants, and helpful discussions;D r. Ben-Ning Cao, Dana-Farber Cancer Institute, for the gift of Gs preparations; Dr. Michael J. Browning, University of Glasgow, for initial experiments performed during postdoctoral studies in C.S.R.{\textquoteleft}s laboratory; Stephen Tapp, for technical assistance;a nd Martha Mahoney for expert support in manuscript preparation.",
year = "1992",
month = jan,
doi = "10.1016/0008-8749(92)90115-6",
language = "English (US)",
volume = "139",
pages = "229--238",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",
}