Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

Lin Wu, Kate E.R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Possemato, Michael E. Pacold, Thales Papagiannakopoulos, Alec C. Kimmelman, Rahul Satija, Dan R. Littman

Research output: Contribution to journalArticlepeer-review

Abstract

Metabolic redundancy differs according to microenvironments, making the glycolysis gene Gpi1 dispensable for homeostatic Th17 cells in normal tissue but essential for pathogenic Th17 cells in hypoxic inflamed tissue.

Original languageEnglish (US)
Pages (from-to)641-654.e20
JournalCell
Volume182
Issue number3
DOIs
StatePublished - Aug 6 2020

Keywords

  • autoimmunity
  • colitis
  • CRISPR
  • EAE
  • glycolysis
  • hypoxia
  • inflammation
  • metabolic plasticity
  • OXPHOS
  • segmented filamentous bacteria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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