Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

Lin Wu; Kate E.R. Hollinshead; Yuhan Hao; Christy Au; Lina Kroehling; Charles Ng; Woan Yu Lin; Dayi Li; Hernandez Moura Silva; Jong Shin; Juan J. Lafaille; Richard Possemato; Michael E. Pacold; Thales Papagiannakopoulos; Alec C. Kimmelman; Rahul Satija; Dan R. Littman

doi:10.1016/j.cell.2020.06.014

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

Lin Wu, Kate E.R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Possemato, Michael E. Pacold, Thales Papagiannakopoulos, Alec C. Kimmelman, Rahul Satija, Dan R. Littman

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Metabolic redundancy differs according to microenvironments, making the glycolysis gene Gpi1 dispensable for homeostatic Th17 cells in normal tissue but essential for pathogenic Th17 cells in hypoxic inflamed tissue.

Original language	English (US)
Pages (from-to)	641-654.e20
Journal	Cell
Volume	182
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2020.06.014
State	Published - Aug 6 2020

Keywords

autoimmunity
colitis
CRISPR
EAE
glycolysis
hypoxia
inflammation
metabolic plasticity
OXPHOS
segmented filamentous bacteria

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2020.06.014

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Wu, L., Hollinshead, K. E. R., Hao, Y., Au, C., Kroehling, L., Ng, C., Lin, W. Y., Li, D., Silva, H. M., Shin, J., Lafaille, J. J., Possemato, R., Pacold, M. E., Papagiannakopoulos, T., Kimmelman, A. C., Satija, R., & Littman, D. R. (2020). Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy. Cell, 182(3), 641-654.e20. https://doi.org/10.1016/j.cell.2020.06.014

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy. / Wu, Lin; Hollinshead, Kate E.R.; Hao, Yuhan; Au, Christy; Kroehling, Lina; Ng, Charles; Lin, Woan Yu; Li, Dayi; Silva, Hernandez Moura; Shin, Jong; Lafaille, Juan J.; Possemato, Richard; Pacold, Michael E.; Papagiannakopoulos, Thales; Kimmelman, Alec C.; Satija, Rahul; Littman, Dan R.

In: Cell, Vol. 182, No. 3, 06.08.2020, p. 641-654.e20.

Research output: Contribution to journal › Article › peer-review

Wu, L, Hollinshead, KER, Hao, Y, Au, C, Kroehling, L, Ng, C, Lin, WY, Li, D, Silva, HM, Shin, J, Lafaille, JJ, Possemato, R, Pacold, ME, Papagiannakopoulos, T, Kimmelman, AC, Satija, R & Littman, DR 2020, 'Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy', Cell, vol. 182, no. 3, pp. 641-654.e20. https://doi.org/10.1016/j.cell.2020.06.014

Wu, Lin ; Hollinshead, Kate E.R. ; Hao, Yuhan ; Au, Christy ; Kroehling, Lina ; Ng, Charles ; Lin, Woan Yu ; Li, Dayi ; Silva, Hernandez Moura ; Shin, Jong ; Lafaille, Juan J. ; Possemato, Richard ; Pacold, Michael E. ; Papagiannakopoulos, Thales ; Kimmelman, Alec C. ; Satija, Rahul ; Littman, Dan R. / Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy. In: Cell. 2020 ; Vol. 182, No. 3. pp. 641-654.e20.

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abstract = "Metabolic redundancy differs according to microenvironments, making the glycolysis gene Gpi1 dispensable for homeostatic Th17 cells in normal tissue but essential for pathogenic Th17 cells in hypoxic inflamed tissue.",

keywords = "autoimmunity, colitis, CRISPR, EAE, glycolysis, hypoxia, inflammation, metabolic plasticity, OXPHOS, segmented filamentous bacteria",

author = "Lin Wu and Hollinshead, {Kate E.R.} and Yuhan Hao and Christy Au and Lina Kroehling and Charles Ng and Lin, {Woan Yu} and Dayi Li and Silva, {Hernandez Moura} and Jong Shin and Lafaille, {Juan J.} and Richard Possemato and Pacold, {Michael E.} and Thales Papagiannakopoulos and Kimmelman, {Alec C.} and Rahul Satija and Littman, {Dan R.}",

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AU - Ng, Charles

AU - Lin, Woan Yu

AU - Li, Dayi

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AU - Shin, Jong

AU - Lafaille, Juan J.

AU - Possemato, Richard

AU - Pacold, Michael E.

AU - Papagiannakopoulos, Thales

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