Nickel-Catalyzed Asymmetric Reductive Diarylation of Vinylarenes

David Anthony, Qiao Lin, Judith Baudet, Tianning Diao

Research output: Contribution to journalArticle

Abstract

A nickel-catalyzed asymmetric diarylation reaction of vinylarenes enables the preparation of chiral α,α,β-triarylated ethane scaffolds, which exist in a number of biologically active molecules. The use of reducing conditions with aryl bromides as coupling partners obviates the need for stoichiometric organometallic reagents and tolerates a broad range of functional groups. The application of an N-oxyl radical as a ligand to a nickel catalyst represents a novel approach to facilitate nickel-catalyzed cross-coupling reactions.

Original languageEnglish (US)
Pages (from-to)3198-3202
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number10
DOIs
StatePublished - Mar 4 2019

Keywords

  • alkenes
  • aryl bromides
  • asymmetric catalysis
  • diarylation
  • nickel

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Nickel-Catalyzed Asymmetric Reductive Diarylation of Vinylarenes'. Together they form a unique fingerprint.

  • Cite this