Nickel-Catalyzed Dicarbofunctionalization of Alkenes

Xiaoxu Qi, Tianning Diao

Research output: Contribution to journalArticlepeer-review

Abstract

1,2-Dicarbofunctionalization of alkenes has emerged as an efficient synthetic strategy for preparing substituted molecules by coupling readily available alkenes with electrophiles and/or nucleophiles. Nickel complexes serve as effective catalysts owing to their tendency to undergo facile oxidative addition and slow β-hydride elimination, and their capability to access both two-electron and radical pathways. Two-component alkene functionalization reactions have achieved high chemo-, regio-, and stereoselectivities by tethering one of the coupling partners to the alkene substrate. Three-component reactions, however, often incorporate directing groups to control the selectivity. Only a few examples of directing-group-free difunctionalizations of unactivated alkenes have been reported. Therefore, great opportunities exist for the development of three-component difunctionalization reactions with broad substrate scopes and tunable chemo-, regio-, and stereoselectivities.

Original languageEnglish (US)
Pages (from-to)8542-8556
Number of pages15
JournalACS Catalysis
Volume10
Issue number15
DOIs
StatePublished - Aug 7 2020

Keywords

  • alkenes
  • dicarbofunctionalization
  • nickel catalysis
  • selectivity

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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