Nirs-based quantitative measurement of autoregulatory effects on microvascular hemoglobin oxygenation: Applications to assessment of traumatic brain injury

Randall L. Barbour, Gerald T. Voelbel, Jean Lengenfelder, Glenn Wylie, Yaling Pei, Harry L. Graber, John DeLuca

Research output: Contribution to conferencePaper

Abstract

Cerebral vascular autoregulation is the process by which the balance between oxygen demand and supply is maintained in brain tissue. We have developed a method for dividing the hemoglobin signal into six discrete categories that correspond to different states of vascular autoregulation. All six states occur continuously throughout the brain, however little is known about their interplay within specified regions of the cortex that subserve specific cognitive tasks. Here we report on a study that investigated cerebral vascular autoregulation (CVA) in three groups of adult subjects during a verbal working memory task: healthy controls, subjects with moderateto- severe traumatic brain injuries, and multiple sclerosis patients. The CVA state analysis performed reveals statistically significant differences between all pairs of subject groups.

Original languageEnglish (US)
PagesBMD1
DOIs
StatePublished - 2008
EventBiomedical Optics, BIOMED 2008 - St. Petersburg, FL, United States
Duration: Mar 16 2008Mar 19 2008

Other

OtherBiomedical Optics, BIOMED 2008
CountryUnited States
CitySt. Petersburg, FL
Period3/16/083/19/08

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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    Barbour, R. L., Voelbel, G. T., Lengenfelder, J., Wylie, G., Pei, Y., Graber, H. L., & DeLuca, J. (2008). Nirs-based quantitative measurement of autoregulatory effects on microvascular hemoglobin oxygenation: Applications to assessment of traumatic brain injury. BMD1. Paper presented at Biomedical Optics, BIOMED 2008, St. Petersburg, FL, United States. https://doi.org/10.1364/biomed.2008.bmd1