Nitrate signaling: Adaptation to fluctuating environments

Gabriel Krouk, Nigel M. Crawford, Gloria M. Coruzzi, Yi Fang Tsay

Research output: Contribution to journalReview articlepeer-review


Nitrate (NO3-) is a key nutrient as well as a signaling molecule that impacts both metabolism and development of plants. Understanding the complexity of the regulatory networks that control nitrate uptake, metabolism, and associated responses has the potential to provide solutions that address the major issues of nitrate pollution and toxicity that threaten agricultural and ecological sustainability and human health. Recently, major advances have been made in cataloguing the nitrate transcriptome and in identifying key components that mediate nitrate signaling. In this perspective, we describe the genes involved in nitrate regulation and how they influence nitrate transport and assimilation, and we discuss the role of systems biology approaches in elucidating the gene networks involved in NO3- signaling adaptation to fluctuating environments.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalCurrent Opinion in Plant Biology
Issue number3
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Plant Science


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