Abstract
Coordinated proliferation and differentiation of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. Recent data demonstrate important roles for nitric oxide (NO) and C-type natriuretic peptide (CNP) in the regulation of cartilage development. Both NO and CNP stimulate the synthesis of cGMP and thus the activation of common downstream pathways. One of these downstream mediators, cGMP-dependent kinase II (cGKII), has itself been shown to be essential for normal endochondral bone formation. This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development.
Original language | English (US) |
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Pages (from-to) | 171-178 |
Number of pages | 8 |
Journal | Developmental Biology |
Volume | 319 |
Issue number | 2 |
DOIs | |
State | Published - Jul 15 2008 |
Keywords
- C-type natriuretic peptide
- Cartilage
- Endochondral bone
- MAPK pathways
- Nitric oxide
- cGMP
- cGMP-dependent kinase
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology