Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification

Cristina C. Teixeira, Hanga Agoston, Frank Beier

Research output: Contribution to journalReview articlepeer-review


Coordinated proliferation and differentiation of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. Recent data demonstrate important roles for nitric oxide (NO) and C-type natriuretic peptide (CNP) in the regulation of cartilage development. Both NO and CNP stimulate the synthesis of cGMP and thus the activation of common downstream pathways. One of these downstream mediators, cGMP-dependent kinase II (cGKII), has itself been shown to be essential for normal endochondral bone formation. This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development.

Original languageEnglish (US)
Pages (from-to)171-178
Number of pages8
JournalDevelopmental Biology
Issue number2
StatePublished - Jul 15 2008


  • C-type natriuretic peptide
  • Cartilage
  • Endochondral bone
  • MAPK pathways
  • Nitric oxide
  • cGMP
  • cGMP-dependent kinase

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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