TY - JOUR
T1 - NLGN1 and NLGN2 in the prefrontal cortex
T2 - their role in memory consolidation and strengthening
AU - Katzman, Aaron
AU - Alberini, Cristina M.
N1 - Funding Information:
We thank Xiaojing Ye and Dana Kapeller-Libermann for discussions on an earlier draft of this manuscript. This work was supported by MH065635 and MH074736 to CMA and T32-MH019524 to AK.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/2
Y1 - 2018/2
N2 - The prefrontal cortex (PFC) is critical for memory formation, but the underlying molecular mechanisms are poorly understood. Clinical and animal model studies have shown that changes in PFC excitation and inhibition are important for cognitive functions as well as related disorders. Here, we discuss recent findings revealing the roles of the excitatory and inhibitory synaptic proteins neuroligin 1 (NLGN1) and NLGN2 in the PFC in memory formation and modulation of memory strength. We propose that shifts in NLGN1 and NLGN2 expression in specific excitatory and inhibitory neuronal subpopulations in response to experience regulate the dynamic processes of memory consolidation and strengthening. Because excitatory/inhibitory imbalances accompany neuropsychiatric disorders in which strength and flexibility of representations play important roles, understanding these mechanisms may suggest novel therapies.
AB - The prefrontal cortex (PFC) is critical for memory formation, but the underlying molecular mechanisms are poorly understood. Clinical and animal model studies have shown that changes in PFC excitation and inhibition are important for cognitive functions as well as related disorders. Here, we discuss recent findings revealing the roles of the excitatory and inhibitory synaptic proteins neuroligin 1 (NLGN1) and NLGN2 in the PFC in memory formation and modulation of memory strength. We propose that shifts in NLGN1 and NLGN2 expression in specific excitatory and inhibitory neuronal subpopulations in response to experience regulate the dynamic processes of memory consolidation and strengthening. Because excitatory/inhibitory imbalances accompany neuropsychiatric disorders in which strength and flexibility of representations play important roles, understanding these mechanisms may suggest novel therapies.
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U2 - 10.1016/j.conb.2017.12.003
DO - 10.1016/j.conb.2017.12.003
M3 - Review article
C2 - 29278843
AN - SCOPUS:85042216336
SN - 0959-4388
VL - 48
SP - 122
EP - 130
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -