Abstract
Site-specifically modified oligonucleotides were derived from the reactions of stereoisomeric polycyclic aromatic diol epoxide metabolite model compounds with oligonucleotides of defined base composition and sequence. The NMR solution structures of ten different adducts studied so far are briefly described, and it is shown that stereochemical factors and the nature of the oligonucleotide context of the complementary strands, exert a powerful influence on the conformational features of these adducts.
Original language | English (US) |
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Pages (from-to) | 153-160 |
Number of pages | 8 |
Journal | Polycyclic Aromatic Compounds |
Volume | 10 |
Issue number | 1-4 |
DOIs | |
State | Published - 1996 |
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry