No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences

Coren L. Apicella, David Cesarini, Magnus Johannesson, Christopher T. Dawes, Paul Lichtenstein, Björn Wallace, Jonathan Beauchamp, Lars Westberg

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Oxytocin (OXT) has been implicated in a suite of complex social behaviors including observed choices in economic laboratory experiments. However, actual studies of associations between oxytocin receptor (OXTR) gene variants and experimentally elicited social preferences are rare. Methodology/Principal Findings: We test hypotheses of associations between social preferences, as measured by behavior in two economic games, and 9 single nucleotide polymorphisms (SNPs) of the OXTR gene in a sample of Swedish twins (n=684). Two standard economic games, the dictator game and the trust game, both involving real monetary consequences, were used to elicit such preferences. After correction for multiple hypothesis testing, we found no significant associations between any of the 9 single nucleotide polymorphisms (SNPs) and behavior in either of the games. Conclusion: We were unable to replicate the most significant association reported in previous research between the amount donated in a dictator game and an OXTR genetic variant.

    Original languageEnglish (US)
    Article numbere11153
    JournalPloS one
    Volume5
    Issue number6
    DOIs
    StatePublished - 2010

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)
    • General

    Fingerprint Dive into the research topics of 'No association between Oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences'. Together they form a unique fingerprint.

    Cite this