Noise-induced transitions in slow wave neuronal dynamics

Sukbin Lim, John Rinzel

Research output: Contribution to journalArticlepeer-review

Abstract

Many neuronal systems exhibit slow random alternations and sudden switches in activity states. Models with noisy relaxation dynamics (oscillatory, excitable or bistable) account for these temporal, slow wave, patterns and the fluctuations within states. The noise-induced transitions in a relaxation dynamics are analogous to escape by a particle in a slowly changing double-well potential. In this formalism, we obtain semi-analytically the first and second order statistical properties: the distributions of the slow process at the transitions and the temporal correlations of successive switching events. We find that the temporal correlations can be used to help distinguish among biophysical mechanisms for the slow negative feedback, such as divisive or subtractive. We develop our results in the context of models for cellular pacemaker neurons; they also apply to mean-field models for spontaneously active networks with slow wave dynamics.

Original languageEnglish (US)
Pages (from-to)1-17
Number of pages17
JournalJournal of Computational Neuroscience
Volume28
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • Bursting
  • Noise effects
  • Noise-induced transitions
  • Pacemaker neuron
  • Relaxation dynamics
  • Respiratory CPG

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Noise-induced transitions in slow wave neuronal dynamics'. Together they form a unique fingerprint.

Cite this