Non-contact continuous-wave diffuse optical tomographic system to capture vascular dynamics in the foot

Jennifer W. Hoi, Hyun K. Kim, Michael A. Khalil, Christopher J. Fong, Alessandro Marone, Gautam Shrikhande, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Dynamic optical tomographic imaging has shown promise in diagnosing and monitoring peripheral arterial disease (PAD), which affects 8 to 12 million in the United States. PAD is the narrowing of the arteries that supply blood to the lower extremities. Prolonged reduced blood flow to the foot leads to ulcers and gangrene, which makes placement of optical fibers for contact-based optical tomography systems difficult and cumbersome. Since many diabetic PAD patients have foot wounds, a non-contact interface is highly desirable. We present a novel non-contact dynamic continuous-wave optical tomographic imaging system that images the vasculature in the foot for evaluating PAD. The system images at up to 1Hz by delivering 2 wavelengths of light to the top of the foot at up to 20 source positions through collimated source fibers. Transmitted light is collected with an electron multiplying charge couple device (EMCCD) camera. We demonstrate that the system can resolve absorbers at various locations in a phantom study and show the system’s first clinical 3D images of total hemoglobin changes in the foot during venous occlusion at the thigh. Our initial results indicate that this system is effective in capturing the vascular dynamics within the foot and can be used to diagnose and monitor treatment of PAD in diabetic patients.

    Original languageEnglish (US)
    Title of host publicationAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
    EditorsTuan Vo-Dinh, Anita Mahadevan-Jansen, Warren S. Grundfest
    PublisherSPIE
    ISBN (Electronic)9781628414035
    DOIs
    StatePublished - 2015
    EventAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII - San Francisco, United States
    Duration: Feb 8 2015Feb 10 2015

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume9313
    ISSN (Print)1605-7422

    Conference

    ConferenceAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
    CountryUnited States
    CitySan Francisco
    Period2/8/152/10/15

    Keywords

    • diffuse optical tomography
    • dynamic imaging
    • Peripheral arterial disease
    • vascular dynamics

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Atomic and Molecular Physics, and Optics
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

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