TY - JOUR
T1 - Non-topotactic phase transformations in single crystals of β-glycine
AU - Jiang, Qi
AU - Shtukenberg, Alexander G.
AU - Ward, Michael D.
AU - Hu, Chunhua
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/6/3
Y1 - 2015/6/3
N2 - The metastable β polymorph of glycine exhibits a single-crystal-to-single-crystal transformation (SCSCT) to either the α or phase with retention of the crystal habit of the parent β phase. X-ray diffraction and optical microscopy reveal that of 51 single crystals of the β parent phase, 24 form single domain crystals of α or with a single orientation matrix, confirming an SCSCT. The remaining 27 β parent crystals transform to crystals with a few domains of either α and/or, each domain arising from a single nucleation event. In three cases the β α and β transformations occurred within the same glycine single crystal. In all cases, regardless of the number of domains, the transformation occurred with retention of the original habit of the parent phase. Both βα and β transformations proceed in a non-topotactic manner, as evident from the random orientations of the daughter phases in the crystallographic reference frame of the parent β phase. The transformation rates, as measured by advancement of the growth front with polarized optical microscopy, vary from crystal to crystal as well as for different regions within the same crystal. Moreover, the transformation rate increases substantially with relative humidity, and at a relative humidity of 90% α-glycine was observed as the only product.
AB - The metastable β polymorph of glycine exhibits a single-crystal-to-single-crystal transformation (SCSCT) to either the α or phase with retention of the crystal habit of the parent β phase. X-ray diffraction and optical microscopy reveal that of 51 single crystals of the β parent phase, 24 form single domain crystals of α or with a single orientation matrix, confirming an SCSCT. The remaining 27 β parent crystals transform to crystals with a few domains of either α and/or, each domain arising from a single nucleation event. In three cases the β α and β transformations occurred within the same glycine single crystal. In all cases, regardless of the number of domains, the transformation occurred with retention of the original habit of the parent phase. Both βα and β transformations proceed in a non-topotactic manner, as evident from the random orientations of the daughter phases in the crystallographic reference frame of the parent β phase. The transformation rates, as measured by advancement of the growth front with polarized optical microscopy, vary from crystal to crystal as well as for different regions within the same crystal. Moreover, the transformation rate increases substantially with relative humidity, and at a relative humidity of 90% α-glycine was observed as the only product.
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U2 - 10.1021/acs.cgd.5b00187
DO - 10.1021/acs.cgd.5b00187
M3 - Article
AN - SCOPUS:84930648893
SN - 1528-7483
VL - 15
SP - 2568
EP - 2573
JO - Crystal Growth and Design
JF - Crystal Growth and Design
IS - 6
ER -