Nonequilibrium phase diagrams for actomyosin networks

Simon L. Freedman, Glen M. Hocky, Shiladitya Banerjee, Aaron R. Dinner

Research output: Contribution to journalArticlepeer-review


Living cells dynamically modulate the local morphologies of their actin networks to perform biological functions, including force transduction, intracellular transport, and cell division. A major challenge is to understand how diverse structures of the actin cytoskeleton are assembled from a limited set of molecular building blocks. Here we study the spontaneous self-assembly of a minimal model of cytoskeletal materials, consisting of semiflexible actin filaments, crosslinkers, and molecular motors. Using coarse-grained simulations, we demonstrate that by changing concentrations and kinetics of crosslinkers and motors, as well as filament lengths, we can generate three distinct structural phases of actomyosin assemblies: bundled, polarity-sorted, and contracted. We introduce new metrics to distinguish these structural phases and demonstrate their functional roles. We find that the binding kinetics of motors and crosslinkers can be tuned to optimize contractile force generation, motor transport, and mechanical response. By quantitatively characterizing the relationships between the modes of cytoskeletal self-assembly, the resulting structures, and their functional consequences, our work suggests new principles for the design of active materials.

Original languageEnglish (US)
Pages (from-to)7740-7747
Number of pages8
JournalSoft Matter
Issue number37
StatePublished - 2018

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics


Dive into the research topics of 'Nonequilibrium phase diagrams for actomyosin networks'. Together they form a unique fingerprint.

Cite this