Nonfluoride caries-preventive agents: Executive summary of evidence-based clinical recommendations

Michael P. Rethman, Eugenio D. Beitrán-Aguilar, Ronald J. Billings, Robert A. Burne, Melinda Clark, Kevin J. Donly, Philippe P. Hujoei, Barry P. Katz, Peter Milgrom, Woosung Sohn, John W. Stamm, Watson Gene Watson, Mark Wolff, J. Tim Wright, Domenick Zero, Aravamudhan Krishna Aravamudhan, Julie Frantsve-Hawley, Daniel M. Meyer

Research output: Contribution to journalArticlepeer-review


Background. In this article, the authors present evidence-based clinical recommendations regarding the use of nonfluoride cariespreventive agents. The recommendations were developed by an expert panel convened by the American Dental Association (ADA) Council on Scientific Affairs. The panel addressed several questions regarding the efficacy of nonfluoride agents in reducing the incidence of caries and arresting or reversing the progression of caries. Types of Studies Reviewed. A panel of experts convened by the ADA Council on Scientific Affairs, in collaboration with ADA Division of Science staff, conducted a MEDLINE search to identify all randomized and nonrandomized clinical studies regarding the use of nonfluoride caries-preventive agents. Results. The panel reviewed evidence from 50 randomized controlled trials and 15 nonrandomized studies to assess the efficacy of various nonfluoride caries-preventive agents. Clinical Implications. The panel concluded that certain nonfluoride agents may provide some benefit as adjunctive therapies in children and adults at higher risk of developing caries. These recommendations are presented as a resource for dentists to consider in the clinical decision-making process. As part of the evidencebased approach to care, these clinical recommendations should be integrated with the practitioner's professional judgment and the patient's needs and preferences.

Original languageEnglish (US)
Pages (from-to)1065-1071
Number of pages7
JournalJournal of the American Dental Association
Issue number9
StatePublished - Sep 2011


  • Acidulated phosphate fluoride
  • Caries
  • Chlorhexidine
  • Clinical recommendations
  • Evidence-based dentistry
  • Xylitol

ASJC Scopus subject areas

  • General Dentistry


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