Noninvasive quantification of intracellular sodium in human brain using ultrahigh-field MRI

Lazar Fleysher, Niels Oesingmann, Ryan Brown, Daniel K. Sodickson, Graham C. Wiggins, Matilde Inglese

Research output: Contribution to journalArticlepeer-review


In vivo sodium magnetic resonance imaging (MRI) measures tissue sodium content in living human brain but current methods do not allow noninvasive quantitative assessment of intracellular sodium concentration (ISC) - the most useful marker of tissue viability. In this study, we report the first noninvasive quantitative in vivo measurement of ISC and intracellular sodium volume fraction (ISVF) in healthy human brain, made possible by measuring tissue sodium concentration (TSC) and intracellular sodium molar fraction (ISMF) at ultra-high field MRI. The method uses single-quantum (SQ) and triple-quantum filtered (TQF) imaging at 7 Tesla to separate intra- and extracellular sodium signals and provide quantification of ISMF, ISC and ISVF. This novel method allows noninvasive quantitative measurement of ISC and ISVF, opening many possibilities for structural and functional metabolic studies in healthy and diseased brains.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalNMR in Biomedicine
Issue number1
StatePublished - Jan 2013


  • Brain
  • Intracellular
  • MR imaging
  • Multiple-quantum filtering
  • Sodium
  • Ultrahigh magnetic field

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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