Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh

Faruque Parvez; Yu Chen; Paul W. Brandt-Rauf; Alfred Bernard; Xavier Dumont; Vesna Slavkovich; Maria Argos; Jeanine D'Armiento; Robert Foronjy; M. Rashidul Hasan; H. E.M. Mahbubul Eunus; Joseph H. Graziano; Habibul Ahsan

doi:10.1289/ehp.9507

Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh

Faruque Parvez, Yu Chen, Paul W. Brandt-Rauf, Alfred Bernard, Xavier Dumont, Vesna Slavkovich, Maria Argos, Jeanine D'Armiento, Robert Foronjy, M. Rashidul Hasan, H. E.M. Mahbubul Eunus, Joseph H. Graziano, Habibul Ahsan

Urban Initiative

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions. Objectives: We examined the relationship of the serum level of Clara cell protein CC16 - a novel biomarker for respiratory illnesses - with well As, total urinary As, and urinary As methylation indices. Methods: We conducted a cross-sectional study in nonsmoking individuals (n = 241) selected from a large cohort with a wide range of As exposure (0.1-761 μg/L) from drinking water in Bangladesh. Total urinary As, urinary As metabolites, and serum CC16 were measured in urine and serum samples collected at baseline of the parent cohort study. Results: We observed an inverse association between urinary As and serum CC16 among persons with skin lesions (β = -0.13, p = 0.01). We also observed a positive association between secondary methylation index in urinary As and CC16 levels (β = 0.12, p = 0.05) in the overall study population; the association was stronger among people without skin lesions (β = 0.18, p = 0.04), indicating that increased methylation capability may be protective against As-induced respiratory damage. In a subsample of study participants undergoing spirometric measures (n = 31), we observed inverse associations between urinary As and predictive FEV₁ (forced expiratory volume measured in 1 sec) (r = -0.37; FEV₁/forced vital capacity ratio and primary methylation index (r = -0.42, p = 0.01). Conclusions: The findings suggest that serum CC16 may be a useful biomarker of epithelial lung damage in individuals with arsenical skin lesions. Also, we observed the deleterious respiratory effects of As exposure at concentrations lower than reported in earlier studies.

Original language	English (US)
Pages (from-to)	190-195
Number of pages	6
Journal	Environmental health perspectives
Volume	116
Issue number	2
DOIs	https://doi.org/10.1289/ehp.9507
State	Published - Feb 2008

Keywords

Arsenic
Bangladesh
CC16
Clara cell 16
Drinking water
Epithelial lung damage
Respiratory illnesses

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1289/ehp.9507

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Parvez, F., Chen, Y., Brandt-Rauf, P. W., Bernard, A., Dumont, X., Slavkovich, V., Argos, M., D'Armiento, J., Foronjy, R., Hasan, M. R., Mahbubul Eunus, H. E. M., Graziano, J. H., & Ahsan, H. (2008). Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh. Environmental health perspectives, 116(2), 190-195. https://doi.org/10.1289/ehp.9507

Parvez, F, Chen, Y, Brandt-Rauf, PW, Bernard, A, Dumont, X, Slavkovich, V, Argos, M, D'Armiento, J, Foronjy, R, Hasan, MR, Mahbubul Eunus, HEM, Graziano, JH & Ahsan, H 2008, 'Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh', Environmental health perspectives, vol. 116, no. 2, pp. 190-195. https://doi.org/10.1289/ehp.9507

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title = "Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh",

abstract = "Background: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions. Objectives: We examined the relationship of the serum level of Clara cell protein CC16 - a novel biomarker for respiratory illnesses - with well As, total urinary As, and urinary As methylation indices. Methods: We conducted a cross-sectional study in nonsmoking individuals (n = 241) selected from a large cohort with a wide range of As exposure (0.1-761 μg/L) from drinking water in Bangladesh. Total urinary As, urinary As metabolites, and serum CC16 were measured in urine and serum samples collected at baseline of the parent cohort study. Results: We observed an inverse association between urinary As and serum CC16 among persons with skin lesions (β = -0.13, p = 0.01). We also observed a positive association between secondary methylation index in urinary As and CC16 levels (β = 0.12, p = 0.05) in the overall study population; the association was stronger among people without skin lesions (β = 0.18, p = 0.04), indicating that increased methylation capability may be protective against As-induced respiratory damage. In a subsample of study participants undergoing spirometric measures (n = 31), we observed inverse associations between urinary As and predictive FEV1 (forced expiratory volume measured in 1 sec) (r = -0.37; FEV1/forced vital capacity ratio and primary methylation index (r = -0.42, p = 0.01). Conclusions: The findings suggest that serum CC16 may be a useful biomarker of epithelial lung damage in individuals with arsenical skin lesions. Also, we observed the deleterious respiratory effects of As exposure at concentrations lower than reported in earlier studies.",

keywords = "Arsenic, Bangladesh, CC16, Clara cell 16, Drinking water, Epithelial lung damage, Respiratory illnesses",

author = "Faruque Parvez and Yu Chen and Brandt-Rauf, {Paul W.} and Alfred Bernard and Xavier Dumont and Vesna Slavkovich and Maria Argos and Jeanine D'Armiento and Robert Foronjy and Hasan, {M. Rashidul} and {Mahbubul Eunus}, {H. E.M.} and Graziano, {Joseph H.} and Habibul Ahsan",

year = "2008",

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doi = "10.1289/ehp.9507",

language = "English (US)",

volume = "116",

pages = "190--195",

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T1 - Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh

AU - Parvez, Faruque

AU - Chen, Yu

AU - Brandt-Rauf, Paul W.

AU - Bernard, Alfred

AU - Dumont, Xavier

AU - Slavkovich, Vesna

AU - Argos, Maria

AU - D'Armiento, Jeanine

AU - Foronjy, Robert

AU - Hasan, M. Rashidul

AU - Mahbubul Eunus, H. E.M.

AU - Graziano, Joseph H.

AU - Ahsan, Habibul

PY - 2008/2

Y1 - 2008/2

N2 - Background: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions. Objectives: We examined the relationship of the serum level of Clara cell protein CC16 - a novel biomarker for respiratory illnesses - with well As, total urinary As, and urinary As methylation indices. Methods: We conducted a cross-sectional study in nonsmoking individuals (n = 241) selected from a large cohort with a wide range of As exposure (0.1-761 μg/L) from drinking water in Bangladesh. Total urinary As, urinary As metabolites, and serum CC16 were measured in urine and serum samples collected at baseline of the parent cohort study. Results: We observed an inverse association between urinary As and serum CC16 among persons with skin lesions (β = -0.13, p = 0.01). We also observed a positive association between secondary methylation index in urinary As and CC16 levels (β = 0.12, p = 0.05) in the overall study population; the association was stronger among people without skin lesions (β = 0.18, p = 0.04), indicating that increased methylation capability may be protective against As-induced respiratory damage. In a subsample of study participants undergoing spirometric measures (n = 31), we observed inverse associations between urinary As and predictive FEV1 (forced expiratory volume measured in 1 sec) (r = -0.37; FEV1/forced vital capacity ratio and primary methylation index (r = -0.42, p = 0.01). Conclusions: The findings suggest that serum CC16 may be a useful biomarker of epithelial lung damage in individuals with arsenical skin lesions. Also, we observed the deleterious respiratory effects of As exposure at concentrations lower than reported in earlier studies.

AB - Background: Arsenic from drinking water has been associated with malignant and nonmalignant respiratory illnesses. The association with nonmalignant respiratory illnesses has not been well established because the assessments of respiratory symptoms may be influenced by recall bias or interviewer bias because participants had visible skin lesions. Objectives: We examined the relationship of the serum level of Clara cell protein CC16 - a novel biomarker for respiratory illnesses - with well As, total urinary As, and urinary As methylation indices. Methods: We conducted a cross-sectional study in nonsmoking individuals (n = 241) selected from a large cohort with a wide range of As exposure (0.1-761 μg/L) from drinking water in Bangladesh. Total urinary As, urinary As metabolites, and serum CC16 were measured in urine and serum samples collected at baseline of the parent cohort study. Results: We observed an inverse association between urinary As and serum CC16 among persons with skin lesions (β = -0.13, p = 0.01). We also observed a positive association between secondary methylation index in urinary As and CC16 levels (β = 0.12, p = 0.05) in the overall study population; the association was stronger among people without skin lesions (β = 0.18, p = 0.04), indicating that increased methylation capability may be protective against As-induced respiratory damage. In a subsample of study participants undergoing spirometric measures (n = 31), we observed inverse associations between urinary As and predictive FEV1 (forced expiratory volume measured in 1 sec) (r = -0.37; FEV1/forced vital capacity ratio and primary methylation index (r = -0.42, p = 0.01). Conclusions: The findings suggest that serum CC16 may be a useful biomarker of epithelial lung damage in individuals with arsenical skin lesions. Also, we observed the deleterious respiratory effects of As exposure at concentrations lower than reported in earlier studies.

KW - Arsenic

KW - Bangladesh

KW - CC16

KW - Clara cell 16

KW - Drinking water

KW - Epithelial lung damage

KW - Respiratory illnesses

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Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh

Abstract

Keywords

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