Nonorthogonal Cascade Catalysis in Multicompartment Micelles

Eman Ahmed, Jinwon Cho, Seung Soon Jang, Marcus Weck

Research output: Contribution to journalArticlepeer-review


Multicompartment micelles (MCMs) containing acid and base sites in discrete domains are prepared from poly(norbornene)-based amphiphilic bottlebrush copolymers in aqueous media. The acid and base sites are localized in different compartments of the micelle, enabling the nonorthogonal reaction sequence: deacetalization – Knoevenagel condensation – Michael addition of acetals to 2-amino chromene derivatives. Computational simulations using dissipative particle dynamics (DPD) elucidated the bottlebrush composition required to effectively site-isolate the nonorthogonal catalysts. This contribution presents MCMs as a new class of nanostructures for one-pot multistep nonorthogonal cascade catalysis, laying the groundwork for the isolation of three or more incompatible catalysts to synthesize value-added compounds in a single reaction vessel, in water.

Original languageEnglish (US)
Article numbere202301231
JournalChemistry - A European Journal
Issue number43
StatePublished - Aug 1 2023


  • acid-base nonorthogonal cascade catalysis
  • bottlebrush block copolymer
  • multicompartment micelles
  • site-isolation
  • supported catalysis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Organic Chemistry


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