Nonpeptidic foldamers from amino acids: Synthesis and characterization of 1,3-substituted triazole oligomers

Nicholas G. Angelo, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review

Abstract

Nonpeptidic foldamers capable of displaying protein-like functionality were prepared by swapping amide bonds with 1,2,3-triazole rings. The overall conformation of these triazole oligomers is largely dictated by dipole-dipole interactions between adjacent rings. Solution NMR studies suggest that a zigzag conformation, which closely mimics the β-strand structure, predominates in two different tetramers.

Original languageEnglish (US)
Pages (from-to)17134-17135
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number49
DOIs
StatePublished - Dec 14 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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