Nonthrombogenic and cell nonadhesive substrates based on polyethylene oxide modified surfaces

Neil P. Desai; Jeffrey A. Hubbell

Nonthrombogenic and cell nonadhesive substrates based on polyethylene oxide modified surfaces

Neil P. Desai, Jeffrey A. Hubbell

Chemical and Biomolecular Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We have previously demonstrated the SPIN (surface physical interpenetrating network) technique of achieving immobilization of PEO/PEG onto the surface of a biomaterial. Polyethylene terephthalate (PET), a polyurethane (pellethane), and polymethyl methacrylate (PMMA) were modified using this technique for PEO incorporation. In the present study we report further analysis of this system in terms of surface characterization, in vivo evaluation, and bacterial adherence. This work reinforces the fact that PEO 18.5k is a suitable modifier in applications that require biologically nonfouling surfaces. The SPIN technique is a simple, versatile, nonchemical method of modifying a substrate or device to acheive these properties.

Original language	English (US)
Pages	295
Number of pages	1
State	Published - 1991
Event	17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium - Scottsdale, AZ, USA Duration: May 1 1991 → May 5 1991

Other

Other	17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium
City	Scottsdale, AZ, USA
Period	5/1/91 → 5/5/91

ASJC Scopus subject areas

General Materials Science

Cite this

Nonthrombogenic and cell nonadhesive substrates based on polyethylene oxide modified surfaces. / Desai, Neil P.; Hubbell, Jeffrey A.
1991. 295 Paper presented at 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium, Scottsdale, AZ, USA.

Research output: Contribution to conference › Paper › peer-review

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AB - We have previously demonstrated the SPIN (surface physical interpenetrating network) technique of achieving immobilization of PEO/PEG onto the surface of a biomaterial. Polyethylene terephthalate (PET), a polyurethane (pellethane), and polymethyl methacrylate (PMMA) were modified using this technique for PEO incorporation. In the present study we report further analysis of this system in terms of surface characterization, in vivo evaluation, and bacterial adherence. This work reinforces the fact that PEO 18.5k is a suitable modifier in applications that require biologically nonfouling surfaces. The SPIN technique is a simple, versatile, nonchemical method of modifying a substrate or device to acheive these properties.

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T2 - 17th Annual Meeting of the Society for Biomaterials in conjunction with the 23rd International Biomaterials Symposium

Y2 - 1 May 1991 through 5 May 1991

ER -

Nonthrombogenic and cell nonadhesive substrates based on polyethylene oxide modified surfaces

Abstract

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ASJC Scopus subject areas

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