Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation

Filipe Pinto-Teixeira, Claude Desplan

Research output: Contribution to journalReview article

Abstract

Asymmetric division of neural progenitor cells is a crucial event in the generation of neuronal diversity and involves the segregation of distinct proteins into daughter cells, thereby promoting unique differentiation programs. Although it was known that Notch signaling acts postmitotically to orchestrate differentiation of daughter cells from asymmetrically dividing precursor cells, Bhat reported a previously uncharacterized role for Notch that occurs before cell division to promote the asymmetric localization of the protein Numb and the positioning of the cleavage furrow. Numb is an inhibitor of Notch activity; thus, this mechanism forms a regulatory feedback loop to control asymmetric cytokinesis and differentiation.

Original languageEnglish (US)
Pages (from-to)pe26
JournalScience signaling
Volume7
Issue number348
DOIs
StatePublished - Oct 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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