Novel genes for familial combined hyperlipidemia

Bradley E. Aouizerat, Hooman Allayee, Jackie Bodnar, Kelly L. Krass, Leena Peltonen, Tjerk W A De Bruin, Jerome I. Rotter, Aldons J. Lusis

Research output: Contribution to journalReview articlepeer-review


Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalCurrent Opinion in Lipidology
Issue number2
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology


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