Novel genes for familial combined hyperlipidemia

Bradley E. Aouizerat; Hooman Allayee; Jackie Bodnar; Kelly L. Krass; Leena Peltonen; Tjerk W A De Bruin; Jerome I. Rotter; Aldons J. Lusis

doi:10.1097/00041433-199904000-00005

Novel genes for familial combined hyperlipidemia

Bradley E. Aouizerat, Hooman Allayee, Jackie Bodnar, Kelly L. Krass, Leena Peltonen, Tjerk W A De Bruin, Jerome I. Rotter, Aldons J. Lusis

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

Original language	English (US)
Pages (from-to)	113-122
Number of pages	10
Journal	Current Opinion in Lipidology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1097/00041433-199904000-00005
State	Published - Apr 1999

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Molecular Biology
Genetics
Nutrition and Dietetics
Cardiology and Cardiovascular Medicine
Cell Biology

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10.1097/00041433-199904000-00005

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title = "Novel genes for familial combined hyperlipidemia",

abstract = "Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.",

author = "Aouizerat, {Bradley E.} and Hooman Allayee and Jackie Bodnar and Krass, {Kelly L.} and Leena Peltonen and {De Bruin}, {Tjerk W A} and Rotter, {Jerome I.} and Lusis, {Aldons J.}",

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T1 - Novel genes for familial combined hyperlipidemia

AU - Aouizerat, Bradley E.

AU - Allayee, Hooman

AU - Bodnar, Jackie

AU - Krass, Kelly L.

AU - Peltonen, Leena

AU - De Bruin, Tjerk W A

AU - Rotter, Jerome I.

AU - Lusis, Aldons J.

PY - 1999/4

Y1 - 1999/4

N2 - Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

AB - Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

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Novel genes for familial combined hyperlipidemia

Abstract

ASJC Scopus subject areas

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