Novel genes for familial combined hyperlipidemia

Bradley E. Aouizerat, Hooman Allayee, Jackie Bodnar, Kelly L. Krass, Leena Peltonen, Tjerk W A De Bruin, Jerome I. Rotter, Aldons J. Lusis

Research output: Contribution to journalReview article

Abstract

Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalCurrent Opinion in Lipidology
Volume10
Issue number2
DOIs
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Genetics
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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  • Cite this

    Aouizerat, B. E., Allayee, H., Bodnar, J., Krass, K. L., Peltonen, L., De Bruin, T. W. A., Rotter, J. I., & Lusis, A. J. (1999). Novel genes for familial combined hyperlipidemia. Current Opinion in Lipidology, 10(2), 113-122. https://doi.org/10.1097/00041433-199904000-00005