Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: Candidate and genome scans of functional SNPs

John P. Kane; Bradley E. Aouizerat; May M. Luke; Dov Shiffman; Olga Iakoubova; Dongming Liu; Charlie M. Rowland; Joseph J. Catanese; Diane U. Leong; Kit F. Lau; Judy Z. Louie; Carmen H. Tong; Linda B. McAllister; Lisa F. Dabby; Thomas A. Ports; Andrew D. Michaels; Christian Zellner; Clive R. Pullinger; Mary J. Malloy; James J. Devlin

doi:10.1016/j.ics.2003.11.002

Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: Candidate and genome scans of functional SNPs

John P. Kane, Bradley E. Aouizerat, May M. Luke, Dov Shiffman, Olga Iakoubova, Dongming Liu, Charlie M. Rowland, Joseph J. Catanese, Diane U. Leong, Kit F. Lau, Judy Z. Louie, Carmen H. Tong, Linda B. McAllister, Lisa F. Dabby, Thomas A. Ports, Andrew D. Michaels, Christian Zellner, Clive R. Pullinger, Mary J. Malloy, James J. Devlin

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Association studies were conducted on a large number of single nucleotide polymorphisms (SNPs) in pooled screening for association with angiographically determined coronary artery disease (CAD) and myocardial infarction (MI), followed by individual genotyping of those showing association. Forty-seven SNPs showed association with severity of CAD in a replication study applying individual genotyping in 1250 patients. Case control analysis of 340 patients with MI and 300 controls revealed significant associations of three novel genes: an immune cell receptor on chromosome 20p (p=0.02), a zinc finger protein on chromosome 3 (p=0.04), and an unknown gene on chromosome 3 (p=0.01). Associations of polymorphisms in three genes with the phenotype of familial combined hyperlipidemia (FCH), Apo A-V, PPAR alpha and microsomal triglyceride transfer protein (MTP) were established, supporting a metabolic model for the disorder based on misdirection of fatty acid metabolism. Congruence of SNP associations in non-alcoholic steatohepatitis suggests overlap of this syndrome with FCH.

Original language	English (US)
Pages (from-to)	309-312
Number of pages	4
Journal	International Congress Series
Volume	1262
Issue number	C
DOIs	https://doi.org/10.1016/j.ics.2003.11.002
State	Published - May 1 2004

Keywords

Atherosclerosis
Combined hyperlipidemia
Coronary artery
Genetics

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.ics.2003.11.002

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Kane, J. P., Aouizerat, B. E., Luke, M. M., Shiffman, D., Iakoubova, O., Liu, D., Rowland, C. M., Catanese, J. J., Leong, D. U., Lau, K. F., Louie, J. Z., Tong, C. H., McAllister, L. B., Dabby, L. F., Ports, T. A., Michaels, A. D., Zellner, C., Pullinger, C. R., Malloy, M. J., & Devlin, J. J. (2004). Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: Candidate and genome scans of functional SNPs. International Congress Series, 1262(C), 309-312. https://doi.org/10.1016/j.ics.2003.11.002

Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: Candidate and genome scans of functional SNPs. / Kane, John P.; Aouizerat, Bradley E.; Luke, May M. et al.
In: International Congress Series, Vol. 1262, No. C, 01.05.2004, p. 309-312.

Research output: Contribution to journal › Article › peer-review

Kane, JP, Aouizerat, BE, Luke, MM, Shiffman, D, Iakoubova, O, Liu, D, Rowland, CM, Catanese, JJ, Leong, DU, Lau, KF, Louie, JZ, Tong, CH, McAllister, LB, Dabby, LF, Ports, TA, Michaels, AD, Zellner, C, Pullinger, CR, Malloy, MJ & Devlin, JJ 2004, 'Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: Candidate and genome scans of functional SNPs', International Congress Series, vol. 1262, no. C, pp. 309-312. https://doi.org/10.1016/j.ics.2003.11.002

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title = "Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: Candidate and genome scans of functional SNPs",

abstract = "Association studies were conducted on a large number of single nucleotide polymorphisms (SNPs) in pooled screening for association with angiographically determined coronary artery disease (CAD) and myocardial infarction (MI), followed by individual genotyping of those showing association. Forty-seven SNPs showed association with severity of CAD in a replication study applying individual genotyping in 1250 patients. Case control analysis of 340 patients with MI and 300 controls revealed significant associations of three novel genes: an immune cell receptor on chromosome 20p (p=0.02), a zinc finger protein on chromosome 3 (p=0.04), and an unknown gene on chromosome 3 (p=0.01). Associations of polymorphisms in three genes with the phenotype of familial combined hyperlipidemia (FCH), Apo A-V, PPAR alpha and microsomal triglyceride transfer protein (MTP) were established, supporting a metabolic model for the disorder based on misdirection of fatty acid metabolism. Congruence of SNP associations in non-alcoholic steatohepatitis suggests overlap of this syndrome with FCH.",

keywords = "Atherosclerosis, Combined hyperlipidemia, Coronary artery, Genetics",

author = "Kane, {John P.} and Aouizerat, {Bradley E.} and Luke, {May M.} and Dov Shiffman and Olga Iakoubova and Dongming Liu and Rowland, {Charlie M.} and Catanese, {Joseph J.} and Leong, {Diane U.} and Lau, {Kit F.} and Louie, {Judy Z.} and Tong, {Carmen H.} and McAllister, {Linda B.} and Dabby, {Lisa F.} and Ports, {Thomas A.} and Michaels, {Andrew D.} and Christian Zellner and Pullinger, {Clive R.} and Malloy, {Mary J.} and Devlin, {James J.}",

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AU - Luke, May M.

AU - Shiffman, Dov

AU - Iakoubova, Olga

AU - Liu, Dongming

AU - Rowland, Charlie M.

AU - Catanese, Joseph J.

AU - Leong, Diane U.

AU - Lau, Kit F.

AU - Louie, Judy Z.

AU - Tong, Carmen H.

AU - McAllister, Linda B.

AU - Dabby, Lisa F.

AU - Ports, Thomas A.

AU - Michaels, Andrew D.

AU - Zellner, Christian

AU - Pullinger, Clive R.

AU - Malloy, Mary J.

AU - Devlin, James J.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - Association studies were conducted on a large number of single nucleotide polymorphisms (SNPs) in pooled screening for association with angiographically determined coronary artery disease (CAD) and myocardial infarction (MI), followed by individual genotyping of those showing association. Forty-seven SNPs showed association with severity of CAD in a replication study applying individual genotyping in 1250 patients. Case control analysis of 340 patients with MI and 300 controls revealed significant associations of three novel genes: an immune cell receptor on chromosome 20p (p=0.02), a zinc finger protein on chromosome 3 (p=0.04), and an unknown gene on chromosome 3 (p=0.01). Associations of polymorphisms in three genes with the phenotype of familial combined hyperlipidemia (FCH), Apo A-V, PPAR alpha and microsomal triglyceride transfer protein (MTP) were established, supporting a metabolic model for the disorder based on misdirection of fatty acid metabolism. Congruence of SNP associations in non-alcoholic steatohepatitis suggests overlap of this syndrome with FCH.

AB - Association studies were conducted on a large number of single nucleotide polymorphisms (SNPs) in pooled screening for association with angiographically determined coronary artery disease (CAD) and myocardial infarction (MI), followed by individual genotyping of those showing association. Forty-seven SNPs showed association with severity of CAD in a replication study applying individual genotyping in 1250 patients. Case control analysis of 340 patients with MI and 300 controls revealed significant associations of three novel genes: an immune cell receptor on chromosome 20p (p=0.02), a zinc finger protein on chromosome 3 (p=0.04), and an unknown gene on chromosome 3 (p=0.01). Associations of polymorphisms in three genes with the phenotype of familial combined hyperlipidemia (FCH), Apo A-V, PPAR alpha and microsomal triglyceride transfer protein (MTP) were established, supporting a metabolic model for the disorder based on misdirection of fatty acid metabolism. Congruence of SNP associations in non-alcoholic steatohepatitis suggests overlap of this syndrome with FCH.

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KW - Combined hyperlipidemia

KW - Coronary artery

KW - Genetics

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Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: Candidate and genome scans of functional SNPs

Abstract

Keywords

ASJC Scopus subject areas

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