TY - JOUR
T1 - Novel Molecular Scaffolds
T2 - Formation of Helical Secondary Structure in a Family of Oligoanthranilamides
AU - Hamuro, Yoshitomo
AU - Geib, Steven J.
AU - Hamilton, Andrew D.
PY - 1994/3/3
Y1 - 1994/3/3
N2 - In a simple reaction sequence 2‐nitrobenzoyl chloride, methyl anthranilate, and 2,6‐bis‐(chloroformyl)pyridine are employed to give oligoanthranilamide 1. This compound has a helical structure in solution and in the solid state, and the pitch of the helix can be altered by synthesis of the corresponding pyridine N‐oxide derivative. These types of mimics of the peptide framework are of interest for the de novo design of proteins and drugs. (Figure Presented.)
AB - In a simple reaction sequence 2‐nitrobenzoyl chloride, methyl anthranilate, and 2,6‐bis‐(chloroformyl)pyridine are employed to give oligoanthranilamide 1. This compound has a helical structure in solution and in the solid state, and the pitch of the helix can be altered by synthesis of the corresponding pyridine N‐oxide derivative. These types of mimics of the peptide framework are of interest for the de novo design of proteins and drugs. (Figure Presented.)
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U2 - 10.1002/anie.199404461
DO - 10.1002/anie.199404461
M3 - Article
AN - SCOPUS:33748216403
SN - 0570-0833
VL - 33
SP - 446
EP - 448
JO - Angewandte Chemie International Edition in English
JF - Angewandte Chemie International Edition in English
IS - 4
ER -