Novel mutifunctional near-infrared fluorescent nanoparticles: Integrating nanotechnology and biophotonics

V. Saxena; M. Sadoqi; S. Kumar; J. Shao

doi:10.1117/12.534329

Novel mutifunctional near-infrared fluorescent nanoparticles: Integrating nanotechnology and biophotonics

V. Saxena, M. Sadoqi, S. Kumar, J. Shao

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The objective of this study is to engineer a novel nanoparticlulate system for use in early tumor diagnosis. Indocyanine green (ICG)-loaded biodegradable nanoparticles were prepared by using biodegradable polymer, poly(DL-lactic-co-glycolic acid) (PLGA). The ICG entrapment, nanoparticle size, shape, zeta potential the release of ICG from nanoparticles was determined. Also, the effect of ICG entrapment on fluorescence spectra of ICG was measured. The engineered nanoparticles were nearly spherical in shape and efficiently entrapped ICG. The release profile of the nanoparticles was exponential. The entrapment of ICG in nanoparticles caused reduction in its peak fluorescence intensity and shifted its wavelength of peak fluorescence to higher values.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	A.N. Cartwright
Pages	29-35
Number of pages	7
Volume	5331
DOIs	https://doi.org/10.1117/12.534329
State	Published - 2004
Event	Nanobiophotonics and Biomedical Applications - San Jose, CA, United States Duration: Jan 26 2004 → Jan 27 2004

Other

Other	Nanobiophotonics and Biomedical Applications
Country/Territory	United States
City	San Jose, CA
Period	1/26/04 → 1/27/04

Keywords

Biophotonics
Fluorescence
Indocyanine green
Nanoparticles
Near-infrared spectroscopy
PLGA

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

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10.1117/12.534329

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Saxena, V, Sadoqi, M, Kumar, S & Shao, J 2004, Novel mutifunctional near-infrared fluorescent nanoparticles: Integrating nanotechnology and biophotonics. in AN Cartwright (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5331, pp. 29-35, Nanobiophotonics and Biomedical Applications, San Jose, CA, United States, 1/26/04. https://doi.org/10.1117/12.534329

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abstract = "The objective of this study is to engineer a novel nanoparticlulate system for use in early tumor diagnosis. Indocyanine green (ICG)-loaded biodegradable nanoparticles were prepared by using biodegradable polymer, poly(DL-lactic-co-glycolic acid) (PLGA). The ICG entrapment, nanoparticle size, shape, zeta potential the release of ICG from nanoparticles was determined. Also, the effect of ICG entrapment on fluorescence spectra of ICG was measured. The engineered nanoparticles were nearly spherical in shape and efficiently entrapped ICG. The release profile of the nanoparticles was exponential. The entrapment of ICG in nanoparticles caused reduction in its peak fluorescence intensity and shifted its wavelength of peak fluorescence to higher values.",

keywords = "Biophotonics, Fluorescence, Indocyanine green, Nanoparticles, Near-infrared spectroscopy, PLGA",

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year = "2004",

doi = "10.1117/12.534329",

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pages = "29--35",

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AU - Kumar, S.

AU - Shao, J.

PY - 2004

Y1 - 2004

N2 - The objective of this study is to engineer a novel nanoparticlulate system for use in early tumor diagnosis. Indocyanine green (ICG)-loaded biodegradable nanoparticles were prepared by using biodegradable polymer, poly(DL-lactic-co-glycolic acid) (PLGA). The ICG entrapment, nanoparticle size, shape, zeta potential the release of ICG from nanoparticles was determined. Also, the effect of ICG entrapment on fluorescence spectra of ICG was measured. The engineered nanoparticles were nearly spherical in shape and efficiently entrapped ICG. The release profile of the nanoparticles was exponential. The entrapment of ICG in nanoparticles caused reduction in its peak fluorescence intensity and shifted its wavelength of peak fluorescence to higher values.

AB - The objective of this study is to engineer a novel nanoparticlulate system for use in early tumor diagnosis. Indocyanine green (ICG)-loaded biodegradable nanoparticles were prepared by using biodegradable polymer, poly(DL-lactic-co-glycolic acid) (PLGA). The ICG entrapment, nanoparticle size, shape, zeta potential the release of ICG from nanoparticles was determined. Also, the effect of ICG entrapment on fluorescence spectra of ICG was measured. The engineered nanoparticles were nearly spherical in shape and efficiently entrapped ICG. The release profile of the nanoparticles was exponential. The entrapment of ICG in nanoparticles caused reduction in its peak fluorescence intensity and shifted its wavelength of peak fluorescence to higher values.

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KW - Fluorescence

KW - Indocyanine green

KW - Nanoparticles

KW - Near-infrared spectroscopy

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Novel mutifunctional near-infrared fluorescent nanoparticles: Integrating nanotechnology and biophotonics

Abstract

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Keywords

ASJC Scopus subject areas

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