Novel mutifunctional near-infrared fluorescent nanoparticles: Integrating nanotechnology and biophotonics

V. Saxena, M. Sadoqi, S. Kumar, J. Shao

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The objective of this study is to engineer a novel nanoparticlulate system for use in early tumor diagnosis. Indocyanine green (ICG)-loaded biodegradable nanoparticles were prepared by using biodegradable polymer, poly(DL-lactic-co-glycolic acid) (PLGA). The ICG entrapment, nanoparticle size, shape, zeta potential the release of ICG from nanoparticles was determined. Also, the effect of ICG entrapment on fluorescence spectra of ICG was measured. The engineered nanoparticles were nearly spherical in shape and efficiently entrapped ICG. The release profile of the nanoparticles was exponential. The entrapment of ICG in nanoparticles caused reduction in its peak fluorescence intensity and shifted its wavelength of peak fluorescence to higher values.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.N. Cartwright
Number of pages7
StatePublished - 2004
EventNanobiophotonics and Biomedical Applications - San Jose, CA, United States
Duration: Jan 26 2004Jan 27 2004


OtherNanobiophotonics and Biomedical Applications
Country/TerritoryUnited States
CitySan Jose, CA


  • Biophotonics
  • Fluorescence
  • Indocyanine green
  • Nanoparticles
  • Near-infrared spectroscopy
  • PLGA

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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