Novel near-infrared nanoparticulate biomarker: Preparation & stability studies

V. Saxena; M. Sadoqi; S. Kumar; J. Shao

doi:10.1117/12.534317

Novel near-infrared nanoparticulate biomarker: Preparation & stability studies

V. Saxena, M. Sadoqi, S. Kumar, J. Shao

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	A.P. Savitsky, L.Y. Brovko, D.J. Bornhop, R. Raghavachari, S.I. Achilefu
Pages	269-275
Number of pages	7
Volume	5329
DOIs	https://doi.org/10.1117/12.534317
State	Published - 2004
Event	Genetically Engineered and Optical Probes for Biomedical Applications II - San Jose, CA, United States Duration: Jan 24 2004 → Jan 27 2004

Other

Other	Genetically Engineered and Optical Probes for Biomedical Applications II
Country/Territory	United States
City	San Jose, CA
Period	1/24/04 → 1/27/04

Keywords

Degradation
Fluorescence
Indocyanine green
Nanoparticles
PLGA
Stability

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

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10.1117/12.534317

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Novel near-infrared nanoparticulate biomarker: Preparation & stability studies. / Saxena, V.; Sadoqi, M.; Kumar, S. et al.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / A.P. Savitsky; L.Y. Brovko; D.J. Bornhop; R. Raghavachari; S.I. Achilefu. Vol. 5329 2004. p. 269-275.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Saxena, V, Sadoqi, M, Kumar, S & Shao, J 2004, Novel near-infrared nanoparticulate biomarker: Preparation & stability studies. in AP Savitsky, LY Brovko, DJ Bornhop, R Raghavachari & SI Achilefu (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5329, pp. 269-275, Genetically Engineered and Optical Probes for Biomedical Applications II, San Jose, CA, United States, 1/24/04. https://doi.org/10.1117/12.534317

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title = "Novel near-infrared nanoparticulate biomarker: Preparation & stability studies",

abstract = "Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.",

keywords = "Degradation, Fluorescence, Indocyanine green, Nanoparticles, PLGA, Stability",

author = "V. Saxena and M. Sadoqi and S. Kumar and J. Shao",

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language = "English (US)",

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pages = "269--275",

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AU - Kumar, S.

AU - Shao, J.

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Y1 - 2004

N2 - Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.

AB - Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.

KW - Degradation

KW - Fluorescence

KW - Indocyanine green

KW - Nanoparticles

KW - PLGA

KW - Stability

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EP - 275

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Savitsky, A.P.

A2 - Brovko, L.Y.

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Y2 - 24 January 2004 through 27 January 2004

ER -

Novel near-infrared nanoparticulate biomarker: Preparation & stability studies

Abstract

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Keywords

ASJC Scopus subject areas

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