Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity

Tomas Venit, S. Raza Mahmood, Martin Endara-Coll, Piergiorgio Percipalle

Research output: Chapter in Book/Report/Conference proceedingChapter


Cytoskeletal proteins are beginning to be considered as key regulators of nuclear function. Among them, actin and myosin have been implicated in numerous tasks, including chromatin regulation, transcription and assembly of nascent ribonucleoprotein complexes. We also know from work performed by several labs that influx of actin and myosin into the nucleus and out of the nucleus is tightly regulated. In particular, in the case of actin, its nucleocytoplasmic import/export cycle is controlled by the importin/exportin system and it correlates with the transcriptional state of the cell. These basic molecular functions of both actin and myosin seem to impact key cellular functions, including development and differentiation as well as the cellular response to DNA damage by directly affecting transcriptional reprograming. These observations are beginning to suggest that actin and myosin could play an important role in consolidating the organization of the mammalian genome and that loss of actin and myosin likely leads to a general instability of the genome. In this chapter, we provide a general background on evidence that actin and myosin are important in key nuclear functions. Following this, we will focus on evidence supporting of a role in genome organization and finally we will discuss increasingly striking results on the role of actin and myosin in the maintenance of genome integrity.

Original languageEnglish (US)
Title of host publicationActin Cytoskeleton in Cancer Progression and Metastasis - Part A
EditorsClément Thomas, Lorenzo Galluzzi
PublisherElsevier Inc.
Number of pages42
ISBN (Print)9780128212813
StatePublished - 2020

Publication series

NameInternational review of cell and molecular biology
ISSN (Print)1937-6448


  • Chromatin regulation
  • DNA damage response
  • Development and differentiation
  • Genome integrity
  • Genome organization
  • Nuclear actin
  • Nuclear myosin
  • Transcriptional regulation
  • Genomic Instability
  • Actins/metabolism
  • Cell Nucleus/metabolism
  • Chromatin/metabolism
  • Humans
  • Myosins/metabolism
  • Animals

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Cell Biology


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