Numerical analysis of the flux and force generated by a correlation ratchet mechanism

Chichia Chiu; Charles S. Peskin

doi:10.1007/s002850100129

Numerical analysis of the flux and force generated by a correlation ratchet mechanism

Chichia Chiu, Charles S. Peskin

Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

The correlation ratchet (CR) has been proposed as a possible mechanism for the operation of biomolecular motors. To test whether a CR mechanism is applicable to any particular motor, it is necessary to evaluate the unloaded velocity and the stall force of the CR mechanism. This paper is concerned with efficient numerical procedures for the determination of these quantities. In particular, the numerical results indicate that the stall force of a CR mechanism is quite limited, despite wide variations of the CR parameters.

Original language	English (US)
Pages (from-to)	479-501
Number of pages	23
Journal	Journal Of Mathematical Biology
Volume	44
Issue number	5
DOIs	https://doi.org/10.1007/s002850100129
State	Published - May 2002

Keywords

Correlation ratchet
Mathematical biology
Modeling
Numerical analysis
Reaction-diffusion equations

ASJC Scopus subject areas

Modeling and Simulation
Agricultural and Biological Sciences (miscellaneous)
Applied Mathematics

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10.1007/s002850100129

Cite this

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AB - The correlation ratchet (CR) has been proposed as a possible mechanism for the operation of biomolecular motors. To test whether a CR mechanism is applicable to any particular motor, it is necessary to evaluate the unloaded velocity and the stall force of the CR mechanism. This paper is concerned with efficient numerical procedures for the determination of these quantities. In particular, the numerical results indicate that the stall force of a CR mechanism is quite limited, despite wide variations of the CR parameters.

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KW - Reaction-diffusion equations

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Numerical analysis of the flux and force generated by a correlation ratchet mechanism

Abstract

Keywords

ASJC Scopus subject areas

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