Nylon/DNA: Single-stranded DNA with a covalently stitched nylon lining

Lei Zhu, Philip S. Lukeman, James W. Canary, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

Original languageEnglish (US)
Pages (from-to)10178-10179
Number of pages2
JournalJournal of the American Chemical Society
Issue number34
StatePublished - Aug 27 2003

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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