Nylon/DNA: Single-stranded DNA with a covalently stitched nylon lining

Lei Zhu; Philip S. Lukeman; James W. Canary; Nadrian C. Seeman

doi:10.1021/ja035186r

Nylon/DNA: Single-stranded DNA with a covalently stitched nylon lining

Lei Zhu, Philip S. Lukeman, James W. Canary, Nadrian C. Seeman

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

Original language	English (US)
Pages (from-to)	10178-10179
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	34
DOIs	https://doi.org/10.1021/ja035186r
State	Published - Aug 27 2003

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja035186r

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abstract = "The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.",

author = "Lei Zhu and Lukeman, {Philip S.} and Canary, {James W.} and Seeman, {Nadrian C.}",

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AU - Zhu, Lei

AU - Lukeman, Philip S.

AU - Canary, James W.

AU - Seeman, Nadrian C.

PY - 2003/8/27

Y1 - 2003/8/27

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AB - The synthesis of DNA/nylon ladder oligomers is described. Three stages of the development are addressed: the synthesis of 2′-β-substituted phosphoramidites, the deprotection/purification protocols of ODNs modified with both amino and carboxyl groups, and amide bond-forming reactions on the ODNs. The established technology and the novel DNA-based ladder oligomer structure opens a pathway to the synthesis of topological molecular objects and networks templated by DNA through versatile DNA nanotechnology. The DNA-based ladder oligomers may find application in the antisense area.

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JO - Journal of the American Chemical Society

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Nylon/DNA: Single-stranded DNA with a covalently stitched nylon lining

Abstract

ASJC Scopus subject areas

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