Obesity and Type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence

D. Leroith, R. Novosyadlyy, E. J. Gallagher, D. Lann, A. Vljayakumar, S. Yakar, Derek Leroith

Research output: Contribution to journalReview article

Abstract

Both obesity and Type 2 diabetes are independently associated with an increased risk of developing cancer and an increased mortality. The etiology is yet to be determined but insulin resistance and hyperinsulinemia maybe important factors. Hyperglycemia, hyperlipidemia and inflammatory cytokines in addition to the insulin-like growth factors are also possible factors involved in the process.

Original languageEnglish (US)
Pages (from-to)S4-S6
JournalExperimental and Clinical Endocrinology and Diabetes
Volume116
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 2008

Keywords

  • Cancer
  • Diabetes
  • Epidemiology
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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