TY - JOUR
T1 - Obsessive compulsive symptoms in individuals at clinical risk for psychosis
T2 - Association with depressive symptoms and suicidal ideation
AU - DeVylder, Jordan E.
AU - Oh, Amy J.
AU - Ben-David, Shelly
AU - Azimov, Neyra
AU - Harkavy-Friedman, Jill M.
AU - Corcoran, Cheryl M.
N1 - Funding Information:
Funding body and agreements: this work was supported by the NIMH grant K23MH066279 (CC), by the NIH National Center for Research Resources and the National Center for Advancing Translational Sciences (UL1 RR024156, NARSAD), by NARSAD (CC) and by the Sackler Institute for Developmental Psychobiology at Columbia (CC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, NARSAD or the Sackler Institute.
Funding Information:
This work was supported by the NIMH grant K23MH066279 (CC), by the NIH National Center for Research Resources and the National Center for Advancing Translational Sciences ( UL1 RR024156, NARSAD ), by NARSAD (CC) and by the Sackler Institute for Developmental Psychobiology at Columbia (CC).
PY - 2012/9
Y1 - 2012/9
N2 - Obsessive-compulsive symptoms, particularly aggressive obsessions, are prevalent in schizophrenia patients and associated with other symptom severity, suicidal ideation and functional impairment. In a psychosis-risk cohort, obsessive-compulsive diagnosis and symptoms were assessed in terms of prevalence and content, and for associations with clinical measures. Obsessive-compulsive symptoms were prevalent in the CHR cohort, as was suicidal ideation. The presence and severity of aggressive obsessions were associated with depression, suicidal ideation and social impairment. The high prevalence of aggressive obsessions and associated suicidal ideation in a clinical high risk cohort, and their relationship to depression, is relevant for risk assessment and treatment strategies.
AB - Obsessive-compulsive symptoms, particularly aggressive obsessions, are prevalent in schizophrenia patients and associated with other symptom severity, suicidal ideation and functional impairment. In a psychosis-risk cohort, obsessive-compulsive diagnosis and symptoms were assessed in terms of prevalence and content, and for associations with clinical measures. Obsessive-compulsive symptoms were prevalent in the CHR cohort, as was suicidal ideation. The presence and severity of aggressive obsessions were associated with depression, suicidal ideation and social impairment. The high prevalence of aggressive obsessions and associated suicidal ideation in a clinical high risk cohort, and their relationship to depression, is relevant for risk assessment and treatment strategies.
KW - Clinical high risk
KW - Obsessions
KW - OCD
KW - Psychosis
KW - Schizophrenia
KW - Suicidal ideation
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U2 - 10.1016/j.schres.2012.07.009
DO - 10.1016/j.schres.2012.07.009
M3 - Article
C2 - 22846651
AN - SCOPUS:84865322580
SN - 0920-9964
VL - 140
SP - 110
EP - 113
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -