Of mice and malaria mutants: Unravelling the genetics of drug resistance using rodent malaria models

J. M R Carlton; Karen Hayton; P. V L Cravo; David Walliker

doi:10.1016/S1471-4922(01)01899-2

Of mice and malaria mutants: Unravelling the genetics of drug resistance using rodent malaria models

J. M R Carlton, Karen Hayton, P. V L Cravo, David Walliker

Research output: Contribution to journal › Review article › peer-review

Abstract

It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.

Original language	English (US)
Pages (from-to)	236-242
Number of pages	7
Journal	Trends in Parasitology
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/S1471-4922(01)01899-2
State	Published - 2001

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/S1471-4922(01)01899-2

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title = "Of mice and malaria mutants: Unravelling the genetics of drug resistance using rodent malaria models",

abstract = "It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.",

author = "Carlton, {J. M R} and Karen Hayton and Cravo, {P. V L} and David Walliker",

note = "Funding Information: Work in the authors{\textquoteright} laboratory was funded by the Medical Research Council of Great Britain. P.V.L.C. is supported by Fundacao Para a Ciencia e Tecnologia of Portugal. We thank Paul Hunt for helpful suggestions regarding the manuscript.",

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AU - Hayton, Karen

AU - Cravo, P. V L

AU - Walliker, David

N1 - Funding Information: Work in the authors’ laboratory was funded by the Medical Research Council of Great Britain. P.V.L.C. is supported by Fundacao Para a Ciencia e Tecnologia of Portugal. We thank Paul Hunt for helpful suggestions regarding the manuscript.

PY - 2001

Y1 - 2001

N2 - It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.

AB - It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.

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Of mice and malaria mutants: Unravelling the genetics of drug resistance using rodent malaria models

Abstract

ASJC Scopus subject areas

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