TY - JOUR
T1 - Of mice and malaria mutants
T2 - Unravelling the genetics of drug resistance using rodent malaria models
AU - Carlton, J. M R
AU - Hayton, Karen
AU - Cravo, P. V L
AU - Walliker, David
PY - 2001
Y1 - 2001
N2 - It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.
AB - It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria control. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites, only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.
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U2 - 10.1016/S1471-4922(01)01899-2
DO - 10.1016/S1471-4922(01)01899-2
M3 - Review article
C2 - 11323308
AN - SCOPUS:0035021982
VL - 17
SP - 236
EP - 242
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 5
ER -