Oligooxopiperazines as nonpeptidic α-helix mimetics

Petra Tošovská, Paramjit S. Arora

Research output: Contribution to journalArticle

Abstract

Chemical Reaction Repretatio A new class of nonpeptidic α-helix mlmetics derived from a-amino acids and featuring chlral backbones is described. NMR and circular dichroism spectroscopies, in combination with molecular modeling studies, provide compelling evidence that ollgooxopiperazlne dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an α-helix.

Original languageEnglish (US)
Pages (from-to)1588-1591
Number of pages4
JournalOrganic Letters
Volume12
Issue number7
DOIs
StatePublished - Apr 2 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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