Oligooxopiperazines as nonpeptidic α-helix mimetics

Petra Tošovská; Paramjit S. Arora

doi:10.1021/ol1003143

Oligooxopiperazines as nonpeptidic α-helix mimetics

Petra Tošovská, Paramjit S. Arora

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Chemical Reaction Repretatio A new class of nonpeptidic α-helix mlmetics derived from a-amino acids and featuring chlral backbones is described. NMR and circular dichroism spectroscopies, in combination with molecular modeling studies, provide compelling evidence that ollgooxopiperazlne dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an α-helix.

Original language	English (US)
Pages (from-to)	1588-1591
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	7
DOIs	https://doi.org/10.1021/ol1003143
State	Published - Apr 2 2010

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1003143

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abstract = "Chemical Reaction Repretatio A new class of nonpeptidic α-helix mlmetics derived from a-amino acids and featuring chlral backbones is described. NMR and circular dichroism spectroscopies, in combination with molecular modeling studies, provide compelling evidence that ollgooxopiperazlne dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an α-helix.",

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Oligooxopiperazines as nonpeptidic α-helix mimetics

Abstract

ASJC Scopus subject areas

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