Abstract
The design and synthesis of small molecule α-helix mimetics has been a productive field over the past decade. These compounds have performed well in a variety of biological systems as functional disruptors of α-helix- mediated protein-protein interactions. In our studies we have continued to develop novel, more biologically compatible scaffolds, which are often easier to assemble and capable of mimicking longer and/or more diverse helices. To this end, we have constructed a new series of i, i+4, i+7 α-helix mimics based on the enaminone scaffold. These molecules represent a step forward in the pursuit of idealized monofacial α-helix mimetics.
Original language | English (US) |
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Pages (from-to) | 7040-7047 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 76 |
Issue number | 17 |
DOIs | |
State | Published - Sep 2 2011 |
ASJC Scopus subject areas
- Organic Chemistry