On a novel coalescent model for genome-wide evolution of copy number variations

Antonina Mitrofanova, Bhubaneswar Mishra

Research output: Contribution to journalArticlepeer-review


Since we are limited in our knowledge of human demographic history and variations of recombination and mutation rates, large-scale computer simulation is a necessary tool in genetics. Here we propose and computationally simulate a model of evolution for unique and segmentally duplicated regions of human genome. Since such segmentally duplicated regions show a complex behaviour of copy number changes, our model will hopefully lead to a better understanding of the evolutionary developments of CNVs, algorithms for associations studies with CNV markers, and finally, for characterising parameters for stochastic diffusion models, describing asymptotic behaviour of evolutionary processes.

Original languageEnglish (US)
Pages (from-to)300-315
Number of pages16
JournalInternational Journal of Data Mining and Bioinformatics
Issue number3
StatePublished - Jun 2010


  • CNVs
  • Coalescent process
  • Copy number polymorphism
  • Copy number variations
  • SDs
  • Segmental duplications

ASJC Scopus subject areas

  • Information Systems
  • General Biochemistry, Genetics and Molecular Biology
  • Library and Information Sciences


Dive into the research topics of 'On a novel coalescent model for genome-wide evolution of copy number variations'. Together they form a unique fingerprint.

Cite this