On the chemical synthesis of new topological structures

Nils A. Baas, Nadrian C. Seeman

Research output: Contribution to journalArticlepeer-review


The construction of chemical species with topological properties is an area of increasing interest. Numerous such structures have been synthesized in recent years, particularly from DNA, which is a natural synthon for these molecules. Recently, higher-order topological structures have been introduced. These hyper-structures consist of combinations of simple structures, such as a Brunnian Link of Brunnian Links or a Hopf Ring of Hopf Rings, or combinations thereof. In this article, we discuss the possibilities of constructing these hyper-structures with real molecules, particularly emphasizing the tools that result from the double helical structure of DNA.

Original languageEnglish (US)
Pages (from-to)220-232
Number of pages13
JournalJournal of Mathematical Chemistry
Issue number1
StatePublished - Jan 2012


  • Brunnian links
  • Chemical topology
  • DNA
  • Higher-order topology
  • Hopf links

ASJC Scopus subject areas

  • General Chemistry
  • Applied Mathematics


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