On the theory of Ψ‐condensation

A. Yu Grosberg, I. Ya Erukhimovitch, E. I. Shakhnovitch

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We suggest a theory of Ψ‐condensation, based on the assumption that a compact DNA particle is a globule, and specifically that a polymer solution is a strongly fluctuating system and that double‐stranded DNA is a stiff homopolymer single‐stranded chain. We show the DNA globule as it appears in a dilute poly(ethylene oxide) (PEO) solution. The corresponding phase transition is investigated in detail. Growth of the PEO concentration should lead to a decrease in the size of the compact particle and to an increase in its optical rotatory power. Conditions are defined at which drastic compaction of DNA takes place, accompanied by the loss of its optic rotatory power, in regions of high PEO concentrations.

    Original languageEnglish (US)
    Pages (from-to)2413-2432
    Number of pages20
    JournalBiopolymers
    Volume21
    Issue number12
    DOIs
    StatePublished - Dec 1982

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Biomaterials
    • Organic Chemistry

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