One-appointment endodontic therapy biological considerations

Louis M. Lin, Jarshen Lin, Paul A. Rosenberg

Research output: Contribution to journalReview articlepeer-review


Background. The authors conducted a literature review to present the best available biological evidence concerning one-appointment endodontic therapy for asymptomatic teeth with apical periodontitis. Types of Studies Reviewed. Because of recent advances in technology, such as rotary engines and nickel-titanium instruments, some practitioners are performing one-appointment endodontic therapy for asymptomatic teeth with apical periodontitis. The authors reviewed the literature, which revealed only a small number of randomized, controlled clinical trials that have been conducted on one-appointment versus multiple-appointment endodontic therapy. Results. As the apical canal preparation is enlarged, a greater percentage of bacteria is eradicated from infected root canals. In addition, sufficiently large apical root canal enlargement facilitates the delivery of antimicrobial irrigant to the apical portion of the canal. However, an association between positive or negative preobturation root canal culture results and the outcome of endodontic treatment has not been well-established. Clinical Implications. The best available evidence, based on a systematic literature review, indicates that one-appointment endodontic therapy may be feasible in selected cases of apical periodontitis in asymptomatic teeth. However, additional randomized, controlled clinical trials are required.

Original languageEnglish (US)
Pages (from-to)1456-1462
Number of pages7
JournalJournal of the American Dental Association
Issue number11
StatePublished - Nov 2007


  • Apical periodontitis
  • One-appointment endodontic therapy
  • Treatment outcome

ASJC Scopus subject areas

  • General Dentistry


Dive into the research topics of 'One-appointment endodontic therapy biological considerations'. Together they form a unique fingerprint.

Cite this