One-pot synthesis of linear triblock terpolymers and their aqueous self-Assembly

Eman Ahmed, C. Tyler Womble, Jinwon Cho, Kristen Dancel-Manning, William J. Rice, Seung Soon Jang, Marcus Weck

Research output: Contribution to journalArticlepeer-review


Compartmentalized micelles are prepared through the self-Assembly of linear triblock terpolymers containing hydrophilic (H), lipophilic (L), and fluorophilic (F) domains. The triblock copolymers were synthesized via living ring-opening metathesis polymerization (ROMP) of norbornene-based monomers. Our terpolymer design offers a facile approach for the synthesis of the target materials with fast polymerization kinetics, complete block incorporation and control over block sequence. Various triblock terpolymers are prepared with variations in block sequence and block ratio and self-Assembled in aqueous media. Interaction parameter (χ) values between each block are determined using a Flory-Huggins based computational model. "Core-shell-corona", "disk-like", "raspberry-like"and "worm-like"morphologies are observed through cryogenic transmission electron microscopy and dissipative particle dynamics simulations.

Original languageEnglish (US)
Pages (from-to)1967-1974
Number of pages8
JournalPolymer Chemistry
Issue number13
StatePublished - Apr 7 2021

ASJC Scopus subject areas

  • Bioengineering
  • Polymers and Plastics
  • Biochemistry
  • Organic Chemistry


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