Onset of Cell Proliferation in the Shortened Gut: Colonic hyperplasia after ileal resection

Samiran Nundy, Daniel Malamud, Huug Obertop, Jerzy Sczerban, Ronald A. Malt

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cytokinetics in colonic mucosa were studied after ileal resection in young female rats. The RNA content of the transverse colon was increased 32% after 7 days; after 14 days the increase was present throughout the colon. The DNA content of the ascending colon increased 29% after 10 days. Specific activity of DNA labeled with [3H-methyl]thymidine was elevated 29% in the ascending colon and elevated 49% in the descending colon on the 7th postoperative day. Colonic cell proliferation is stimulated within 1 week of ileal resection.

    Original languageEnglish (US)
    Pages (from-to)263-266
    Number of pages4
    JournalGastroenterology
    Volume72
    Issue number2
    DOIs
    StatePublished - 1977

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

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