@article{c0969d677600467ebd499ed9ad9aabfd,
title = "Open access resource for cellular-resolution analyses of corticocortical connectivity in the marmoset monkey",
abstract = "Understanding the principles of neuronal connectivity requires tools for efficient quantification and visualization of large datasets. The primate cortex is particularly challenging due to its complex mosaic of areas, which in many cases lack clear boundaries. Here, we introduce a resource that allows exploration of results of 143 retrograde tracer injections in the marmoset neocortex. Data obtained in different animals are registered to a common stereotaxic space using an algorithm guided by expert delineation of histological borders, allowing accurate assignment of connections to areas despite interindividual variability. The resource incorporates tools for analyses relative to cytoarchitectural areas, including statistical properties such as the fraction of labeled neurons and the percentage of supragranular neurons. It also provides purely spatial (parcellation-free) data, based on the stereotaxic coordinates of 2 million labeled neurons. This resource helps bridge the gap between high-density cellular connectivity studies in rodents and imaging-based analyses of human brains.",
author = "Piotr Majka and Shi Bai and Sophia Bakola and Sylwia Bednarek and Chan, {Jonathan M.} and Natalia Jermakow and Lauretta Passarelli and Reser, {David H.} and Panagiota Theodoni and Worthy, {Katrina H.} and Wang, {Xiao Jing} and W{\'o}jcik, {Daniel K.} and Mitra, {Partha P.} and Rosa, {Marcello G.P.}",
note = "Funding Information: The authors would like to acknowledge the efforts of many other individuals who spent many hours examining the experimental materials under the microscope, conducting digital image analysis, or developing software components, which made this resource possible, including Dr. Nafiseh Atapour, Dr. Kathleen Burman, Lorenzo Canalini, Dr. Michela Gamberini, Dr. Daniele Impieri, Daria Malamanova, Susan Palmer, Jan Maka{\c ,} Karyn Richardson, Maciej {\'S}migielski, Gabriela Saworska, Ianina H. Wolkowicz, Amanda Worthy and Sherry Zhao, Technical support from Kirsty Watkins in conducting histological processing, and the contributions of Dr. Tristan Chaplin and Dr. Hsin-Hao Yu to early phases of the development of the methods are also gratefully acknowledged. This work utilized the Multi-modal Australian ScienceS Imaging and Visualization Environment (MASSIVE) high-performance computing infrastructure (https://www.massive. org.au/), and scanning of histological slides was performed by the Monash Histology Platform (https://platforms.monash.edu/histology/). Funding for the experiments and for the development of the resource was provided by the Australian Research Council (DP110101200, DP140101968, CE140100007), the National Health and Medical Research Council (APP1003906, APP1020839, APP1083152, APP1082144, APP1122220), the International Neuroinformatics Coordinating Facility (INCF Seed Funding grant scheme), the European Regional Development Fund under the Operational Program Innovative Economy (POIG.02.03.00-00-003/09), the National Centre for Research and Development (ERA-NET-NEURON/17/2017), the National Institute of Mental Health (R01MH062349), the Office of Naval Research (N00014-17-1-2041), Cold Spring Harbor Laboratory (Crick-Clay Professorship), the Mathers Foundation, and the Indian Institute of Technology Madras (H. N. Mahabala Chair).",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41467-020-14858-0",
language = "English (US)",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}