Opiate receptor avidity in the thalamus is sexually dimorphic in the elderly

Walter Woodson, Claudia R. Farb, Joseph E. Ledoux

Research output: Contribution to journalArticle

Abstract

Opiate receptor avidity (B'(max)/K(D)), was measured in the subcortex of nine females (five healthy subjects, four Alzheimer patients) and 15 males (seven healthy subjects, eight Alzheimer patients), 51-75 years of age, with the opiate receptor antagonist 6-deoxy-6-β-[18F]fluoronaltrexone (cyclofoxy, CF) and a positron emission tomograph. CF avidity was 27.5% less in the thalamus of healthy women compared to healthy men and 48.5% less in Alzheimer disease female patients compared to male patients. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)226-229
Number of pages4
JournalSynapse
Volume38
Issue number2
DOIs
StatePublished - 2000

Keywords

  • 6-deoxy-6-β[F]fluoronaltrexone
  • Basal ganglia
  • Positron emission tomography

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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