Optical control of TRPV1 channels

Marco Stein; Andreas Breit; Timm Fehrentz; Thomas Gudermann; Dirk Trauner

doi:10.1002/anie.201302530

Optical control of TRPV1 channels

Marco Stein, Andreas Breit, Timm Fehrentz, Thomas Gudermann, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity.

Original language	English (US)
Pages (from-to)	9845-9848
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	37
DOIs	https://doi.org/10.1002/anie.201302530
State	Published - Sep 9 2013

Keywords

TRPV1
azobenzenes
capsaicin
capsazepine
photopharmacology

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201302530

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abstract = "Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity.",

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author = "Marco Stein and Andreas Breit and Timm Fehrentz and Thomas Gudermann and Dirk Trauner",

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AU - Stein, Marco

AU - Breit, Andreas

AU - Fehrentz, Timm

AU - Gudermann, Thomas

AU - Trauner, Dirk

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Y1 - 2013/9/9

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AB - Controlling pain with light: TRPV1 channels mediate the response to noxious heat and can be activated by capsaicin, the major ingredient of chili pepper. Novel azobenzene photoswitches can be used for the optical control of TRPV1. One of these compounds antagonizes capsaicin in a light-dependent fashion, demonstrating that a photoswitchable antagonist and an agonist can be applied in concert to modulate ion channel activity.

KW - TRPV1

KW - azobenzenes

KW - capsaicin

KW - capsazepine

KW - photopharmacology

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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Optical control of TRPV1 channels

Abstract

Keywords

ASJC Scopus subject areas

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