TY - JOUR
T1 - Optical Manipulation of F-Actin with Photoswitchable Small Molecules
AU - Borowiak, Malgorzata
AU - Küllmer, Florian
AU - Gegenfurtner, Florian
AU - Peil, Sebastian
AU - Nasufovic, Veselin
AU - Zahler, Stefan
AU - Thorn-Seshold, Oliver
AU - Trauner, Dirk
AU - Arndt, Hans Dieter
N1 - Publisher Copyright:
Copyright © 2020 American Chemical Society.
PY - 2020/5/20
Y1 - 2020/5/20
N2 - Cell-permeable photoswitchable small molecules, termed optojasps, are introduced to optically control the dynamics of the actin cytoskeleton and cellular functions that depend on it. These light-dependent effectors were designed from the F-actin-stabilizing marine depsipeptide jasplakinolide by functionalizing them with azobenzene photoswitches. As demonstrated, optojasps can be employed to control cell viability, cell motility, and cytoskeletal signaling with the high spatial and temporal resolution that light affords. Optojasps can be expected to find applications in diverse areas of cell biological research. They may also provide a template for photopharmacology targeting the ubiquitous actin cytoskeleton with precision control in the micrometer range.
AB - Cell-permeable photoswitchable small molecules, termed optojasps, are introduced to optically control the dynamics of the actin cytoskeleton and cellular functions that depend on it. These light-dependent effectors were designed from the F-actin-stabilizing marine depsipeptide jasplakinolide by functionalizing them with azobenzene photoswitches. As demonstrated, optojasps can be employed to control cell viability, cell motility, and cytoskeletal signaling with the high spatial and temporal resolution that light affords. Optojasps can be expected to find applications in diverse areas of cell biological research. They may also provide a template for photopharmacology targeting the ubiquitous actin cytoskeleton with precision control in the micrometer range.
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U2 - 10.1021/jacs.9b12898
DO - 10.1021/jacs.9b12898
M3 - Article
C2 - 32388980
AN - SCOPUS:85085687533
SN - 0002-7863
VL - 142
SP - 9240
EP - 9249
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 20
ER -